Metal Complexes with 8-Hydroxyquinoline: Synthesis and <i>In Vitro</i>Antimicrobial Activity  

作　　者：Amira Cipurković Emir Horozić Snjež ana Marić Lejla Mekić Halid Junuzović Amira Cipurković;Emir Horozić;Snježana Marić;Lejla Mekić;Halid Junuzović(Faculty of Natural Sciences and Mathematics, University of Tuzla, Tuzla, Bosnia and Herzegovina;Faculty of Technology, University of Tuzla, Tuzla, Bosnia and Herzegovina;Faculty of Pharmacy, University of Tuzla, Tuzla, Bosnia and Herzegovina)

机构地区：[1]Faculty of Natural Sciences and Mathematics, University of Tuzla, Tuzla, Bosnia and Herzegovina [2]Faculty of Technology, University of Tuzla, Tuzla, Bosnia and Herzegovina [3]Faculty of Pharmacy, University of Tuzla, Tuzla, Bosnia and Herzegovina

出　　处：《Open Journal of Applied Sciences》2021年第1期1-10,共10页应用科学（英文）

摘　　要：In this paper, three complexes with 8-hydroxyquinoline (8-HQ) were synthesized, their spectral analysis was performed and the antimicrobial effect was examined <em>in vitro</em>. The stoichiometric ratio of the complex was determined conductometrically and spectrophotometrically. FTIR and UV/VIS spectroscopy were used for structural characterization. Antimicrobial activity was examined by diffusion technique on selected gram-positive and gram-negative bacteria, and<em> C. albicans</em>. Square planar and octahedral geometry complexes were synthesized by mixing in a molar ratio of 1:2 (M:L). Based on the spectral data, it is concluded that both oxygen and nitrogen atoms from 8-HQ are involved in the formation of the complex. The antimicrobial activity of the complexes is high, with zones of inhibition in the range of 15 - 28 mm. 8-HQ was shown to have a significantly higher ability to inhibit the growth of the tested microorganisms.In this paper, three complexes with 8-hydroxyquinoline (8-HQ) were synthesized, their spectral analysis was performed and the antimicrobial effect was examined <em>in vitro</em>. The stoichiometric ratio of the complex was determined conductometrically and spectrophotometrically. FTIR and UV/VIS spectroscopy were used for structural characterization. Antimicrobial activity was examined by diffusion technique on selected gram-positive and gram-negative bacteria, and<em> C. albicans</em>. Square planar and octahedral geometry complexes were synthesized by mixing in a molar ratio of 1:2 (M:L). Based on the spectral data, it is concluded that both oxygen and nitrogen atoms from 8-HQ are involved in the formation of the complex. The antimicrobial activity of the complexes is high, with zones of inhibition in the range of 15 - 28 mm. 8-HQ was shown to have a significantly higher ability to inhibit the growth of the tested microorganisms.

关 键 词：8-HQ Metal Complex Antimicrobial Activity In Vitro Study 

分 类 号：O62[理学—有机化学]