Photodegradation of Atorvastatin under Light Conditions Relevant to Natural Waters and Photoproducts Toxicity Assessment  

作　　者：Šárka Klementová Pavla Petráňová Pavla Fojtíková Šárka Klementová;Pavla Petráňová;Pavla Fojtíková(Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic)

机构地区：[1]Faculty of Science, University of South Bohemia, Č eské Budějovice, Czech Republic

出　　处：《Open Journal of Applied Sciences》2021年第4期489-499,共11页应用科学（英文）

摘　　要：Atorvastatin, widely prescribed hypolipidemic drug, undergoes rapid, probably self-sensitised, degradation (less than 20% left after 25-minute irradiation) if irradiated by wavelengths 300 - 350 nm in aqueous solution. When ferric ions are added to the reaction mixture, the degradation follows first order kinetics with a rate constant of 0.130 min^{<span style="white-space:nowrap;"><span style="white-space:nowrap;">&#8722;</span></span>1}. Photochemical degradation may thus represent a significant way of environmental transformation of this pharmaceutical. Toxicity testing of atorvastatin and atorvastatin photoproducts performed on the water plant <em>Lemna minor</em> revealed that atorvastatin itself exhibited no observable toxic effect measured as leaf area growth inhibition, while the photoproducts showed a significant toxicity to the plant, which shows the extreme importance of investigating not only toxicity of drugs themselves on aquatic organisms but also effects of their transformation products.Atorvastatin, widely prescribed hypolipidemic drug, undergoes rapid, probably self-sensitised, degradation (less than 20% left after 25-minute irradiation) if irradiated by wavelengths 300 - 350 nm in aqueous solution. When ferric ions are added to the reaction mixture, the degradation follows first order kinetics with a rate constant of 0.130 min^{<span style="white-space:nowrap;"><span style="white-space:nowrap;">&#8722;</span></span>1}. Photochemical degradation may thus represent a significant way of environmental transformation of this pharmaceutical. Toxicity testing of atorvastatin and atorvastatin photoproducts performed on the water plant <em>Lemna minor</em> revealed that atorvastatin itself exhibited no observable toxic effect measured as leaf area growth inhibition, while the photoproducts showed a significant toxicity to the plant, which shows the extreme importance of investigating not only toxicity of drugs themselves on aquatic organisms but also effects of their transformation products.

关 键 词：Atoravastatin PHOTODEGRADATION Atorvastatin and Photoproducts Toxicity Lemna minor 

分 类 号：O64[理学—物理化学]