New Triterpenoid Isolated from the Roots of Gouania longipetala Hemsl  

作　　者：Anderson Claver Kimou Kouamé Jean-Michel Koffi Seri Chardin Seri Zachée Louis Evariste Akissi Kurouindé Viviane Nemlin Akoua Philomène Yao-Kouassi Laurence Voutquenne-Nazabadioko Anderson Claver Kimou;Kouamé Jean-Michel Koffi;Seri Chardin Seri;Zachée Louis Evariste Akissi;Kurouindé Viviane Nemlin;Akoua Philomène Yao-Kouassi;Laurence Voutquenne-Nazabadioko(Laboratoire de Constitution et Raction de la Matire, UFR Sciences des Structures de la Matire et de Technologie, Universit Flix Houphout-Boigny, Abidjan, Cte dIvoire;Laboratoire des Procds Industriels de Synthse, de lEnvironnement et des Energies Nouvelles (LAPISEN), Institut National Polytechnique Flix Houphout-Boigny de Yamoussoukro, Yamoussoukro, Cte dIvoire;UMR 7312, Institut de Chimie Molculaire de Reims (ICMR), Chimie des Substances Naturelles (CNRS), Universit de Reims Champagne-Ardenne, Reims, France;Classe Prparatoires aux Grandes Ecoles (CPGE), Universit de San Pedro, San Pedro, Cte dIvoire)

机构地区：[1]Laboratoire de Constitution et Raction de la Matire, UFR Sciences des Structures de la Matire et de Technologie, Universit Flix Houphout-Boigny, Abidjan, Cte dIvoire [2]Laboratoire des Procds Industriels de Synthse, de lEnvironnement et des Energies Nouvelles (LAPISEN), Institut National Polytechnique Flix Houphout-Boigny de Yamoussoukro, Yamoussoukro, Cte dIvoire [3]UMR 7312, Institut de Chimie Molculaire de Reims (ICMR), Chimie des Substances Naturelles (CNRS), Universit de Reims Champagne-Ardenne, Reims, France [4]Classe Prparatoires aux Grandes Ecoles (CPGE), Universit de San Pedro, San Pedro, Cte dIvoire

出　　处：《Open Journal of Applied Sciences》2024年第11期3069-3076,共8页应用科学（英文）

摘　　要：Gouania longipetala Hemsl. (Rhamnaceae) is a medicinal plant from Côte d’Ivoire used to treat many diseases like malaria, gastrointestinal infections and gout. Scientific research of aerial part revealed the presence of triterpenoid compounds, saponins, phenolic compounds and flavonoids and also mentioned antibacterial, antioxydant and anti-inflammatory activities. Despite the various therapeutic uses of the plant, no scientific research mentions the chemical content of the root. So, this phytochemical investigation is made to identify secondary metabolites present in the hydromethanolic extract of its roots. And the research led to the isolation and characterization of three lupane-type triterpenoid compounds: a novel compound derived from gouanic acid, lupeol (1) and betulin (2), which had been previously reported in the literature. The newly discovered lupane-triterpenoid was identified as 1α-hydroxy-lup-20(29)-en-3-oxo-27,28-dioic acid (3). The structures of these compounds were determined based on analyses of spectroscopic data, including 1D-NMR, 2D-NMR and HR-ESI-MS techniques.Gouania longipetala Hemsl. (Rhamnaceae) is a medicinal plant from Côte d’Ivoire used to treat many diseases like malaria, gastrointestinal infections and gout. Scientific research of aerial part revealed the presence of triterpenoid compounds, saponins, phenolic compounds and flavonoids and also mentioned antibacterial, antioxydant and anti-inflammatory activities. Despite the various therapeutic uses of the plant, no scientific research mentions the chemical content of the root. So, this phytochemical investigation is made to identify secondary metabolites present in the hydromethanolic extract of its roots. And the research led to the isolation and characterization of three lupane-type triterpenoid compounds: a novel compound derived from gouanic acid, lupeol (1) and betulin (2), which had been previously reported in the literature. The newly discovered lupane-triterpenoid was identified as 1α-hydroxy-lup-20(29)-en-3-oxo-27,28-dioic acid (3). The structures of these compounds were determined based on analyses of spectroscopic data, including 1D-NMR, 2D-NMR and HR-ESI-MS techniques.

关 键 词：Gouania longipetala RHAMNACEAE Lupane-Type Triterpenoids 

分 类 号：O62[理学—有机化学]