Changes in the Physical and Mechanical Properties of Human Blood with Sustained Prophylactic Use of Acetylsalicylic Acid (Aspirin)—A Rheological Study  

作　　者：Trevor Corrigan Liam O’Malley Dorian Bailey Hope Moseley Jada Okaikoi Thomas Brown Sean Murray William Chang Minseo Yang Lam Nguyen Erin Milner Kevin O’Donovan Matthew Armstrong Trevor Corrigan;Liam O’Malley;Dorian Bailey;Hope Moseley;Jada Okaikoi;Thomas Brown;Sean Murray;William Chang;Minseo Yang;Lam Nguyen;Erin Milner;Kevin O’Donovan;Matthew Armstrong(Department of Chemistry & Life Science, United States Military Academy, West Point, New York, USA)

机构地区：[1]Department of Chemistry & Life Science, United States Military Academy, West Point, New York, USA

出　　处：《Open Journal of Fluid Dynamics》2021年第4期167-176,共10页流体动力学（英文）

摘　　要：While the prophylactic use of regular, low dosage, acetylsalicylic acid (aspirin) has been employed due to the inhibitory effect on platelet aggregation, few if any rheological studies validate the change in the physical and mechanical properties of human blood post-aspirin administration. The viscosity and yield stress of blood from eleven donors were assessed at varied shear rates before and after daily aspirin administration (81 mg) for 14 consecutive days. The findings indicate a statistically relevant aggregated decrease with respect to viscosity and yield stress within the study population.While the prophylactic use of regular, low dosage, acetylsalicylic acid (aspirin) has been employed due to the inhibitory effect on platelet aggregation, few if any rheological studies validate the change in the physical and mechanical properties of human blood post-aspirin administration. The viscosity and yield stress of blood from eleven donors were assessed at varied shear rates before and after daily aspirin administration (81 mg) for 14 consecutive days. The findings indicate a statistically relevant aggregated decrease with respect to viscosity and yield stress within the study population.

关 键 词：HEMORHEOLOGY Rouleaux 

分 类 号：TG1[金属学及工艺—金属学]