Analysis of Hemoglobin Electrophoresis Results and Their Clinical Significance in Neonates from Beiliu City  

作　　者：Haiquan Li Jinhua Wei Huan Zhao Haiquan Li;Jinhua Wei;Huan Zhao(Department of Laboratory, Beiliu Maternal and Child Health Hospital, Yulin, China;Department of Laboratory, Longan Maternal and Child Health Hospital, Nanning, China;Department of Laboratory, Chongzuo Maternal and Child Health Hospital, Chongzuo, China)

机构地区：[1]Department of Laboratory, Beiliu Maternal and Child Health Hospital, Yulin, China [2]Department of Laboratory, Longan Maternal and Child Health Hospital, Nanning, China [3]Department of Laboratory, Chongzuo Maternal and Child Health Hospital, Chongzuo, China

出　　处：《Advances in Bioscience and Biotechnology》2024年第12期687-695,共9页生命科学与技术进展(英文)

摘　　要：Objective: This study aims to analyze the results of hemoglobin electrophoresis in newborns from Beiliu City to assess the occurrence rate of hemoglobin abnormalities, understand the distribution of different types of hemoglobin variants, and provide a basis for neonatal disease screening and early intervention. Methods: A total of 4134 newborns born at Beiliu Maternity and Child Health Hospital from January to December 2023 were included in this study. The capillary electrophoresis analyzer CAPILLARYS 2 (Sebia, France) was used to analyze umbilical cord blood samples from newborns, assessing the distribution of different hemoglobin types. Statistical analysis was performed using SPSS version 26.0, with results presented as frequencies and percentages. Results: Among the 4134 newborns, there were 2230 male infants and 1904 female infants, showing a significant gender ratio difference (X2 = 51.42, P Conclusion: The results of hemoglobin electrophoresis show a significant difference in the ratio of male to female newborns in Beiliu City. The detection rates of hemoglobins A, F, A2, and others vary, with a relatively low incidence of abnormal hemoglobins, but a significant association with family history. Special attention is needed for abnormalities in hemoglobins F and A2, underscoring the importance of neonatal blood health screening. The findings indicate the presence of hemoglobin variants, suggesting a need for enhanced monitoring and intervention.Objective: This study aims to analyze the results of hemoglobin electrophoresis in newborns from Beiliu City to assess the occurrence rate of hemoglobin abnormalities, understand the distribution of different types of hemoglobin variants, and provide a basis for neonatal disease screening and early intervention. Methods: A total of 4134 newborns born at Beiliu Maternity and Child Health Hospital from January to December 2023 were included in this study. The capillary electrophoresis analyzer CAPILLARYS 2 (Sebia, France) was used to analyze umbilical cord blood samples from newborns, assessing the distribution of different hemoglobin types. Statistical analysis was performed using SPSS version 26.0, with results presented as frequencies and percentages. Results: Among the 4134 newborns, there were 2230 male infants and 1904 female infants, showing a significant gender ratio difference (X2 = 51.42, P Conclusion: The results of hemoglobin electrophoresis show a significant difference in the ratio of male to female newborns in Beiliu City. The detection rates of hemoglobins A, F, A2, and others vary, with a relatively low incidence of abnormal hemoglobins, but a significant association with family history. Special attention is needed for abnormalities in hemoglobins F and A2, underscoring the importance of neonatal blood health screening. The findings indicate the presence of hemoglobin variants, suggesting a need for enhanced monitoring and intervention.

关 键 词：NEWBORNS HEMOGLOBIN ELECTROPHORESIS Blood Screening Genetic Diseases 

分 类 号：F42[经济管理—产业经济]