Antimicrobial Susceptibility and Sub-MIC Biofilm Formation of <i>Moraxella catarrhalis</i>Clinical Isolates under Anaerobic Conditions  

作　　者：Balbina J. Plotkin Thomas Hatakeyama Zheng Ma 

机构地区：[1]Department of Microbiology and Immunology, Midwestern University, Downers Grove, Illinois, USA

出　　处：《Advances in Microbiology》2015年第4期244-251,共8页微生物学（英文）

摘　　要：A medium was developed to support the anaerobic growth and antimicrobial susceptibility testing of clinical Moraxella catarrhalis isolates. The MICs of clinical Moraxella catarrhalis isolates under anaerobic conditions were, in general, decreased as compared to atmospheric or capnophilic conditions, while the MBCs for all conditions were within a 2 fold concentration dilution. Biofilm formation was affected by the presence of sub-MIC concentrations of azithromycin and the tested quinolones with the exception of levofloxacin.A medium was developed to support the anaerobic growth and antimicrobial susceptibility testing of clinical Moraxella catarrhalis isolates. The MICs of clinical Moraxella catarrhalis isolates under anaerobic conditions were, in general, decreased as compared to atmospheric or capnophilic conditions, while the MBCs for all conditions were within a 2 fold concentration dilution. Biofilm formation was affected by the presence of sub-MIC concentrations of azithromycin and the tested quinolones with the exception of levofloxacin.

关 键 词：ANAEROBIC Nitrate Otitis Media Sinusitis Pneumonia BIOFILM Sub-MIC ANAEROBIC Respiration MORAXELLA catarrhalis 

分 类 号：R37[医药卫生—病原生物学]