Cardiac Tolerance of Hydroalcoholic Extract of Bark of Terminalia mantaly H. Perrier (HAEBTM) in Wistar Rats  

作　　者：Irié Lou Bohila Emilie Kamo Kouakou Serge Kouassi Virginie Atto Allico Joseph Djaman Jean David N’guessan Mireille Dosso Irié Lou Bohila Emilie Kamo;Kouakou Serge Kouassi;Virginie Atto;Allico Joseph Djaman;Jean David N’guessan;Mireille Dosso(Department of Microbiology, Institut Pasteur of Cte dIvoire, Abidjan, Cte dIvoire;Biology and Health Laboratory, Flix Houphout-Boigny University, Abidjan, Cte dIvoire;Department of Medical and Fundamental Biochemistry, Institut Pasteur of Cte dIvoire, Abidjan, Cte dIvoire)

机构地区：[1]Department of Microbiology, Institut Pasteur of Cte dIvoire, Abidjan, Cte dIvoire [2]Biology and Health Laboratory, Flix Houphout-Boigny University, Abidjan, Cte dIvoire [3]Department of Medical and Fundamental Biochemistry, Institut Pasteur of Cte dIvoire, Abidjan, Cte dIvoire

出　　处：《American Journal of Molecular Biology》2024年第3期126-137,共12页美国分子生物学期刊（英文）

摘　　要：Terminalia mantaly H. Perrier is a plant used in traditional medicine for the treatment of various pathologies. However, Terminalia mantaly H. Perrier could present potential health effects on patients. In order to determine the possible cardiotoxic effects of the hydro-alcoholic extract of the bark of Terminalia mantaly H. Perrier, (HAEBTM) forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used. Animals in group 1 received distilled water and were used as a control group. On the other hand, groups 2, 3, 4 received oral administration a volume of the hydroalcoholic extract of Terminalia mantaly H. Perrier corresponding to 1 mL/100g of body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate cardiac biochemical markers using spectrophotometric methods using a Cobas C311 HITACHI biochemistry system. After one month of study, all rats were euthanized by overdose of ether, and the hearts of the rats were removed for gross morphological and histopathological analysis. Results were analysed using variance analysis (ANOVA) to compare outcomes as a function of doses administered and treatment times. The biochemical parameters ALT, LDH, CPK, CPKMB showed no significant change (p Terminalia mantaly showed no lesions, edema and necrosis. These results suggest that the hydroalcoholic extract of Terminalia mantaly did not interfere with the functioning or alter the integrity of the heart.Terminalia mantaly H. Perrier is a plant used in traditional medicine for the treatment of various pathologies. However, Terminalia mantaly H. Perrier could present potential health effects on patients. In order to determine the possible cardiotoxic effects of the hydro-alcoholic extract of the bark of Terminalia mantaly H. Perrier, (HAEBTM) forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used. Animals in group 1 received distilled water and were used as a control group. On the other hand, groups 2, 3, 4 received oral administration a volume of the hydroalcoholic extract of Terminalia mantaly H. Perrier corresponding to 1 mL/100g of body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate cardiac biochemical markers using spectrophotometric methods using a Cobas C311 HITACHI biochemistry system. After one month of study, all rats were euthanized by overdose of ether, and the hearts of the rats were removed for gross morphological and histopathological analysis. Results were analysed using variance analysis (ANOVA) to compare outcomes as a function of doses administered and treatment times. The biochemical parameters ALT, LDH, CPK, CPKMB showed no significant change (p Terminalia mantaly showed no lesions, edema and necrosis. These results suggest that the hydroalcoholic extract of Terminalia mantaly did not interfere with the functioning or alter the integrity of the heart.

关 键 词：Terminalia mantaly Bio Cardiac Tolerance Biochemical Markers HISTOPATHOLOGY 

分 类 号：R28[医药卫生—中药学]