Evaluation of Biochemical and Molecular Parameters of Patients Suffering from Chronic Viral Hepatitis B Treated by a Medicinal Plant Recipe of a Health Care Practitioner in Burkina Faso  

作　　者：Pengdwendé Fabienne Ingrid Zongo Bagora Bayala Tampoubila Edwige Yelemkoure Marc Donald Wilfried Adico Jean Marie Compaore Jacques Simpore Pengdwendé Fabienne Ingrid Zongo;Bagora Bayala;Tampoubila Edwige Yelemkoure;Marc Donald Wilfried Adico;Jean Marie Compaore;Jacques Simpore(Universit Joseph KI-ZERBO, Dpartement de Biochimie-Microbiologie, Laboratoire de Biologie Molculaire et de Gntique (LABIOGENE), Ouagadougou, Burkina Faso;Centre de Recherche Biomolculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso;Ecole Normale Suprieure, Koudougou, Burkina Faso;TIIG LA TIIM, Ouagadougou, Burkina Faso)

机构地区：[1]Universit Joseph KI-ZERBO, Dpartement de Biochimie-Microbiologie, Laboratoire de Biologie Molculaire et de Gntique (LABIOGENE), Ouagadougou, Burkina Faso [2]Centre de Recherche Biomolculaire Pietro Annigoni (CERBA), Ouagadougou, Burkina Faso [3]Ecole Normale Suprieure, Koudougou, Burkina Faso [4]TIIG LA TIIM, Ouagadougou, Burkina Faso

出　　处：《American Journal of Molecular Biology》2024年第4期201-210,共10页美国分子生物学期刊（英文）

摘　　要：Chronic viral hepatitis B (HBV) remains a major public health problem in Burkina Faso. Since access to diagnostic tests and treatments is limited because of their high cost, the majority of the population turn to traditional herbal treatments. This study aimed to evaluate the effectiveness of a plant recipe called Hepatib tiben. It consisted of comparing certain biochemical and molecular parameters of patients infected with HBV that were supported by the recipe. The patients were recruited in Ouagadougou by the traditional health practitioner according to the requirements of the study. Thus 44 patients aged 20 to 61 years and carrier of HBsAg for at least 06 months were treated with Hepatib tiben. The tests were performed in the laboratory before and three months after the treatment. ELISA tests were used to confirm the presence of HBsAg and search for anti-HCV antibodies;transaminases, creatinine were quantified by the “Chem 400” automaton and the viral load of HBV by Real-time PCR. The analysis of the results reveals an improvement of the biochemical and molecular parameters of the patients with the following means (ASAT: 21.02 ± 9.97;ALAT: 21.11 ± 13.27;DNA: 1571.82 ± 3990.97 with p = 0.01 for each). As for HBsAg, its disappearance was observed in 4.55% of patients after treatment. The evaluation of the creatinine parameter explained that the recipe of plants has a tolerated effect on the kidneys of treated patients. These results, while encouraging, need to be complemented by further research for the development of effective phytomedicine to treat and eliminate this viral hepatitis B virus.Chronic viral hepatitis B (HBV) remains a major public health problem in Burkina Faso. Since access to diagnostic tests and treatments is limited because of their high cost, the majority of the population turn to traditional herbal treatments. This study aimed to evaluate the effectiveness of a plant recipe called Hepatib tiben. It consisted of comparing certain biochemical and molecular parameters of patients infected with HBV that were supported by the recipe. The patients were recruited in Ouagadougou by the traditional health practitioner according to the requirements of the study. Thus 44 patients aged 20 to 61 years and carrier of HBsAg for at least 06 months were treated with Hepatib tiben. The tests were performed in the laboratory before and three months after the treatment. ELISA tests were used to confirm the presence of HBsAg and search for anti-HCV antibodies;transaminases, creatinine were quantified by the “Chem 400” automaton and the viral load of HBV by Real-time PCR. The analysis of the results reveals an improvement of the biochemical and molecular parameters of the patients with the following means (ASAT: 21.02 ± 9.97;ALAT: 21.11 ± 13.27;DNA: 1571.82 ± 3990.97 with p = 0.01 for each). As for HBsAg, its disappearance was observed in 4.55% of patients after treatment. The evaluation of the creatinine parameter explained that the recipe of plants has a tolerated effect on the kidneys of treated patients. These results, while encouraging, need to be complemented by further research for the development of effective phytomedicine to treat and eliminate this viral hepatitis B virus.

关 键 词：Viral Hepatitis B RECIPE Plants Treatment Burkina Faso 

分 类 号：R51[医药卫生—内科学]