Laxative Effect of Some Plants Extracts Used in Traditional Pharmacopoeia on the Intestine of Rabbit  

作　　者：Imar Djibrine Soudy Arada Izzedine Abdelaziz Djidda Alhadj Ousmane Dahab Atteib Boukar Abba Alifa Djimalbaye Mandiguel Ngomde Djasnabaye Hassane Mahamat Hassane Imar Djibrine Soudy;Arada Izzedine Abdelaziz;Djidda Alhadj;Ousmane Dahab Atteib;Boukar Abba Alifa;Djimalbaye Mandiguel;Ngomde Djasnabaye;Hassane Mahamat Hassane(Institut de Recherche en élevage pour le Développement (IRED), Route de Farcha, N’Djamena, Tchad;Institut National Supérieur des Sciences et Techniques d’Abéché (INSTA), Abéché, Tchad;Laboratoire de Biodiversité et Développement Durable, Université de Ngaoundéré, Ngaoundéré, Cameroun)

机构地区：[1]Institut de Recherche en élevage pour le Développement (IRED), Route de Farcha, N’Djamena, Tchad [2]Institut National Supérieur des Sciences et Techniques d’Abéché (INSTA), Abéché, Tchad [3]Laboratoire de Biodiversité et Développement Durable, Université de Ngaoundéré, Ngaoundéré, Cameroun

出　　处：《Food and Nutrition Sciences》2016年第12期1182-1190,共9页食品与营养科学（英文）

摘　　要：Constipation is a condition in which a person or animal has difficulty in eliminating solid waste from the body and the faeces are hard and dry. It is mainly characterized by a difficulty in defecation. The aim of the study is to assess the laxative effect of some plants such as Adansonia digitata , Ziziphus mauritiana and Psidium guayava traditionally used in Chad to treat the problems of constipation. The Microdynamometer method (Biomecatronics) is used to carry out this study. The outcomes show that the extracts’ leaves of Psidium guayava and barks of Ziziphus mauritiana did not lead a significant contraction of duodenum of rabbit until a maximum concentration of 1000 μg, but the extracts’ leaves of Adansonia digitata had a significant effect (P < 0.05) on the intestinal motility of rabbit. This effect of the extract of Adansonia digitata varies with the increase of its concentration (dose dependent) with a maximum of 500 μg and the minimal effect is inferior to 10 μg. On the other hand, the extract of Adansonia digitata has a musculotrope effect because the results have shown that inhibitive molecules such as the atropine and the naloxone do not have to inhibit the action of Adansonia digitata on the intestinal motility of rabbit. Thus, the extract of this plant would reduce significantly the time of intestinal transit and it will be an important laxative drug candidate as described traditionally in Chad.Constipation is a condition in which a person or animal has difficulty in eliminating solid waste from the body and the faeces are hard and dry. It is mainly characterized by a difficulty in defecation. The aim of the study is to assess the laxative effect of some plants such as Adansonia digitata , Ziziphus mauritiana and Psidium guayava traditionally used in Chad to treat the problems of constipation. The Microdynamometer method (Biomecatronics) is used to carry out this study. The outcomes show that the extracts’ leaves of Psidium guayava and barks of Ziziphus mauritiana did not lead a significant contraction of duodenum of rabbit until a maximum concentration of 1000 μg, but the extracts’ leaves of Adansonia digitata had a significant effect (P < 0.05) on the intestinal motility of rabbit. This effect of the extract of Adansonia digitata varies with the increase of its concentration (dose dependent) with a maximum of 500 μg and the minimal effect is inferior to 10 μg. On the other hand, the extract of Adansonia digitata has a musculotrope effect because the results have shown that inhibitive molecules such as the atropine and the naloxone do not have to inhibit the action of Adansonia digitata on the intestinal motility of rabbit. Thus, the extract of this plant would reduce significantly the time of intestinal transit and it will be an important laxative drug candidate as described traditionally in Chad.

关 键 词：CONSTIPATION Intestinal Contraction RABBIT Adansonia digitata Psidium guayava Ziziphus mauritiana 

分 类 号：R28[医药卫生—中药学]