Single Oral Administration of Anthocyanin Rescues Smoking-Induced Endothelial Dysfunction in Young Smokers but Facilitates Oxidative Stress in Non-Smokers  

作　　者：Akane Yoshizaki Toshiko Tomisawa Tomohiro Osanai Naoki Nanashima Maiko Kitajima Kasumi Mikami Toshifumi Fujita Hayato Maeda Yoji Kato 

机构地区：[1]Hirosaki University Medical Hospital, Hirosaki, Japan [2]Department of Nursing Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan [3]Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan [4]Department of Disability and Health, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan [5]Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Japan [6]Faculty of Education, Hirosaki University, Hirosaki, Japan

出　　处：《Food and Nutrition Sciences》2018年第3期179-190,共12页食品与营养科学（英文）

摘　　要：Objectives: Smoking causes endothelial dysfunction, but it still remains unclear whether oral administration of anthocyanin brings benefits to endothelial function and redox states in young healthy smokers. We tested the hypothesis that supplement anthocyanin may rescue endothelial dysfunction and redox states in young healthy smokers. Methods: Young healthy male non-smoker (n = 8) and smokers (n = 14) were enrolled to measure the derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) levels and brachial artery flow-mediated dilation (FMD) before and 2 hours after one cigarette smoking or resting under administration of blackcurrant supplements (anthocyanins 210 mg) or not. Results: FMD, d-ROMs, and BAP at baseline were similar between non-smokers and smokers. One cigarette smoking induced a decrease in FMD at 2 hours (9.0% ± 2.6% vs 7.5% ± 2.3%, p Conclusions: Single oral administration of anthocyanin rescued smoking-induced endothelial dysfunction in young healthy smokers, but facilitated oxidative stress in non-smokers. When anthocyanin is taken as supplements, it seems important to pay attention to the dose and timing of administration.Objectives: Smoking causes endothelial dysfunction, but it still remains unclear whether oral administration of anthocyanin brings benefits to endothelial function and redox states in young healthy smokers. We tested the hypothesis that supplement anthocyanin may rescue endothelial dysfunction and redox states in young healthy smokers. Methods: Young healthy male non-smoker (n = 8) and smokers (n = 14) were enrolled to measure the derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) levels and brachial artery flow-mediated dilation (FMD) before and 2 hours after one cigarette smoking or resting under administration of blackcurrant supplements (anthocyanins 210 mg) or not. Results: FMD, d-ROMs, and BAP at baseline were similar between non-smokers and smokers. One cigarette smoking induced a decrease in FMD at 2 hours (9.0% ± 2.6% vs 7.5% ± 2.3%, p Conclusions: Single oral administration of anthocyanin rescued smoking-induced endothelial dysfunction in young healthy smokers, but facilitated oxidative stress in non-smokers. When anthocyanin is taken as supplements, it seems important to pay attention to the dose and timing of administration.

关 键 词：BLACKCURRANT ANTHOCYANIN YOUNG Health SMOKER Oxidative Stress Antioxidants 

分 类 号：R5[医药卫生—内科学]