Yacon Product(PBY)Modulates Intestinal Constipation and Protects the Integrity of Crypts in Wistar Rats  

作　　者：Monica de Souza Lima Sant’Anna Vivian Carolina Rodrigues Tatiane Ferreira Araujo Tania Toledo de Oliveira Maria do Carmo Gouveia Peluzio Celia Lucia de Luces Fortes Ferreira 

机构地区：[1]Nutrition Course.Federal University of Rio de Janeiro,Campus Macaé,Macaé,Brazil [2]Department of Food Technology,Federal University of Vicosa,Vicosa,Brazil [3]Nutrition Course,Pitagoras College,Ipatinga,Brazil [4]Department of Biochemistry and Molecular Biology,Federal University of Vicosa,Vicosa,Brazil [5]Departament of Nutrition and Health,Federal University of Vicosa,Vicosa,Brazil

出　　处：《Food and Nutrition Sciences》2018年第12期1391-1407,共17页食品与营养科学（英文）

基　　金：supported by the National Council of Scientific and Technological Development—CNPq;the Foundation for Research Support of the State of Minas Gerais—FAPEMIG.

摘　　要：This study investigated the use of a product based on yacon (PBY) in microbiological, physical-chemical and intestinal characteristics of Wistar rats artificially constipated with Loperamide&reg;. Thirty-two rats were divided into four groups: Control (C), Constipated Control (CC), PBY (not constipated) and Constipated PBY (PBYC). The dosage of 0.14 g of FOS+ inulin/kg was tested. Microbiota, pH and faeces characteristics of faeces and caecal contents were evaluated. Caecal weight, morphometry of caecal villi and the concentration of short-chain fatty acids were determined. Higher caecal weight was identified in the PBYC animals as well as higher width, height and depth of cripts. The PBY group showed the highest (p < 0.05) concentration of butyrate (93.2 ± 65.5 mmol/L). The supplementation with PBY positively altered the intestine epithelial tissue in constipated animals, keeping the integrity of the caecum crypts.This study investigated the use of a product based on yacon (PBY) in microbiological, physical-chemical and intestinal characteristics of Wistar rats artificially constipated with Loperamide&reg;. Thirty-two rats were divided into four groups: Control (C), Constipated Control (CC), PBY (not constipated) and Constipated PBY (PBYC). The dosage of 0.14 g of FOS+ inulin/kg was tested. Microbiota, pH and faeces characteristics of faeces and caecal contents were evaluated. Caecal weight, morphometry of caecal villi and the concentration of short-chain fatty acids were determined. Higher caecal weight was identified in the PBYC animals as well as higher width, height and depth of cripts. The PBY group showed the highest (p < 0.05) concentration of butyrate (93.2 ± 65.5 mmol/L). The supplementation with PBY positively altered the intestine epithelial tissue in constipated animals, keeping the integrity of the caecum crypts.

关 键 词：Prebiotic YACON Single Chain Fatty Acid CONSTIPATION 

分 类 号：R5[医药卫生—内科学]