Influence of Omega 3 Fatty Acid Supplementation on Phase Angle Values of People Living with HIV/AIDS with Lipodystrophy Secondary to Antiretroviral Therapy: A Randomized Clinical Trial  

作　　者：Thalita Bandeira Dantas Alline Peralta Castro Fernando de Souza Flexa Ribeiro Filho Rosana Maria Feio Libonati Thalita Bandeira Dantas;Alline Peralta Castro;Fernando de Souza Flexa Ribeiro Filho;Rosana Maria Feio Libonati(Núcleo de Medicina Tropical do Pará, Programa de Pós graduaç,ã,o em Patologia das Doenç,as Tropicais, Universidade Federal do Pará, Pará, Brasil;Instituto de Ciências Biológicas e da Saúde, Faculdade de Medicina, Universidade Federal do Pará, Pará, Brasil;Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Pará, Pará, Brasil)

机构地区：[1]Núcleo de Medicina Tropical do Pará, Programa de Pós graduaç,ã,o em Patologia das Doenç,as Tropicais, Universidade Federal do Pará, Pará, Brasil [2]Instituto de Ciências Biológicas e da Saúde, Faculdade de Medicina, Universidade Federal do Pará, Pará, Brasil [3]Centro de Ciências Biológicas e da Saúde, Universidade Estadual do Pará, Pará, Brasil

出　　处：《Food and Nutrition Sciences》2024年第1期58-70,共13页食品与营养科学（英文）

摘　　要：Objective: The measurement of phase angles is an important monitoring parameter and supplementation with omega-3 could promote benefits by modulating the electrical potential of membranes and increasing body cell mass. This study aimed to evaluate the effectiveness of omega-3 fatty acid supplementation on the phase angle of people living with HIV/AIDS. Methods: In this study, 63 individuals of all genders who were undergoing outpatient follow-up and showed lipodystrophy due to highly active antiretroviral therapy were analyzed. Our sample consisted of two groups, one that received supplementation containing 2550 mg of omega-3/day (1080 mg of eicosapentaenoic acid and 720 mg of docosahexaenoic acid) for three months (n = 32) and another that underwent nutrition guidance (n = 31). Phase angle and body cell mass were assessed for both groups and compared at the beginning of research (T0) and after our intervention (T1) for each group separately. Results: Phase angle averaged 6.45° ± 1.06 SD. The comparison between T0 and T1 showed a significant increase in phase angle and body cell mass, whereas the guidance group showed a decrease in body cell mass at T1 in relation to T0, with a significant p-value. Variance in phase angle between moments showed significant values between T0 and T1 in the supplementation group for all genders. Conclusion: Omega-3 positively modulated patients phase angle and body cell mass, but we emphasize the need for other studies that can solidify knowledge about supplementation dosage and intervention time.Objective: The measurement of phase angles is an important monitoring parameter and supplementation with omega-3 could promote benefits by modulating the electrical potential of membranes and increasing body cell mass. This study aimed to evaluate the effectiveness of omega-3 fatty acid supplementation on the phase angle of people living with HIV/AIDS. Methods: In this study, 63 individuals of all genders who were undergoing outpatient follow-up and showed lipodystrophy due to highly active antiretroviral therapy were analyzed. Our sample consisted of two groups, one that received supplementation containing 2550 mg of omega-3/day (1080 mg of eicosapentaenoic acid and 720 mg of docosahexaenoic acid) for three months (n = 32) and another that underwent nutrition guidance (n = 31). Phase angle and body cell mass were assessed for both groups and compared at the beginning of research (T0) and after our intervention (T1) for each group separately. Results: Phase angle averaged 6.45° ± 1.06 SD. The comparison between T0 and T1 showed a significant increase in phase angle and body cell mass, whereas the guidance group showed a decrease in body cell mass at T1 in relation to T0, with a significant p-value. Variance in phase angle between moments showed significant values between T0 and T1 in the supplementation group for all genders. Conclusion: Omega-3 positively modulated patients phase angle and body cell mass, but we emphasize the need for other studies that can solidify knowledge about supplementation dosage and intervention time.

关 键 词：HIV LIPODYSTROPHY Omega-3 Phase Angle 

分 类 号：R51[医药卫生—内科学]