Estimation of the galanthamine using derivative spectrophotometry in bulk drug and formulation  

作　　者：Karan Mittal Ramni Kaushal Rajashree Mashru Arti Thakkar 

机构地区：[1]不详

出　　处：《Journal of Biomedical Science and Engineering》2010年第4期439-441,共3页生物医学工程（英文）

摘　　要：Two simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for the determination of galanthamine hydrobromide (GH) in bulk and pharmaceutical formulation. First method is zero order UV spectrophotometry and second is 1st derivative zero crossing spectrophotometry. The developed methods have shown best results in terms of linearity, accuracy, precision, LOD and LOQ for bulk drugs and marketed formulations. Absorbance was measured at 287 nm for zero order and 277.4 nm for first derivative. It obeyed Lambert-Beer’s law in the range of 30-80 μg mL-1. Both methods have good linearity (r2 = 0.9997) and accuracy found to be 100.5% and 101.2% for both methods respectively.Two simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for the determination of galanthamine hydrobromide (GH) in bulk and pharmaceutical formulation. First method is zero order UV spectrophotometry and second is 1st derivative zero crossing spectrophotometry. The developed methods have shown best results in terms of linearity, accuracy, precision, LOD and LOQ for bulk drugs and marketed formulations. Absorbance was measured at 287 nm for zero order and 277.4 nm for first derivative. It obeyed Lambert-Beer’s law in the range of 30-80 μg mL-1. Both methods have good linearity (r2 = 0.9997) and accuracy found to be 100.5% and 101.2% for both methods respectively.

关 键 词：alanthamine Hydrobromide (GH) ZERO Order UV-SPECTROPHOTOMETRY First Derivative ZERO CROSSING SPECTROPHOTOMETRY 

分 类 号：O6[理学—化学]