Elevated Cobalt, Chromium and Molybdenum Levels in Peripheral Blood Have No Effect on the Development of Heterotopic Ossifications after Metal-on-Metal Total Hip Arthroplasty  

作　　者：Alexander J. Pfister Karl-Heinz Widmer Niklaus F. Friederich Martin Majewski Alexander J. Pfister;Karl-Heinz Widmer;Niklaus F. Friederich;Martin Majewski(Department of Anaesthesiology, Hospital of Bülach, Bülach, Switzerland;Department of Orthopaedic Surgery and Traumatology, Hospital of Schaffhausen, Schaffhausen, Switzerland;Department of Orthopaedic Surgery and Traumatology, University of Basel, Basel, Switzerland)

机构地区：[1]Department of Anaesthesiology, Hospital of Bülach, Bülach, Switzerland [2]Department of Orthopaedic Surgery and Traumatology, Hospital of Schaffhausen, Schaffhausen, Switzerland [3]Department of Orthopaedic Surgery and Traumatology, University of Basel, Basel, Switzerland

出　　处：《Journal of Biomedical Science and Engineering》2016年第1期25-40,共16页生物医学工程（英文）

摘　　要：Metal debris from metal-on-metal (MoM) total hip arthroplasties (THA) has been suspected to cause periprosthetic heterotopic ossifications (HO). We determined the influence of disseminated cobalt, chromium and molybdenum on the development of HO. Native blood samples from patients with 86 high-carbon and 16 low-carbon Co28Cr6Mo articulations were analysed by high-resolution inductively coupled plasma mass-spectrometry (HR ICP-MS). The results revealed that high-carbon metal-on-metal articulations showed lower metal blood levels (Co 1.03 to 1.60 μg/l, Cr 0.77 to 0.88 μg/l, Mo 0.45 to 0.56 μg/l) whereas low-carbon articulations achieved higher metal blood levels (Co 2.59 to 6.85 μg/l, Cr 1.25 to 3.55 μg/l, Mo 0.45 to 0.64 μg/l), but no correlation between metal ion blood level or carbon content and the development of HO could be found in these MoM articulations. Hence, metal debris from MoM articulation does not stimulate heterotopic bone formation despite other well-known local reactions.Metal debris from metal-on-metal (MoM) total hip arthroplasties (THA) has been suspected to cause periprosthetic heterotopic ossifications (HO). We determined the influence of disseminated cobalt, chromium and molybdenum on the development of HO. Native blood samples from patients with 86 high-carbon and 16 low-carbon Co28Cr6Mo articulations were analysed by high-resolution inductively coupled plasma mass-spectrometry (HR ICP-MS). The results revealed that high-carbon metal-on-metal articulations showed lower metal blood levels (Co 1.03 to 1.60 μg/l, Cr 0.77 to 0.88 μg/l, Mo 0.45 to 0.56 μg/l) whereas low-carbon articulations achieved higher metal blood levels (Co 2.59 to 6.85 μg/l, Cr 1.25 to 3.55 μg/l, Mo 0.45 to 0.64 μg/l), but no correlation between metal ion blood level or carbon content and the development of HO could be found in these MoM articulations. Hence, metal debris from MoM articulation does not stimulate heterotopic bone formation despite other well-known local reactions.

关 键 词：Wear Total Hip Arthroplasty COBALT CHROMIUM MOLYBDENUM Heterotopic Ossification 

分 类 号：TG1[金属学及工艺—金属学]