Trace Element Analysis in Sera of Horses with Allergic Dermatitis and in Matched Healthy Controls with Special Attention to Zn, Ni and Ti  

作　　者：Raija Hallamaa Sirpa Peräniemi Raija Hallamaa;Sirpa Peräniemi(Veterinary Clinic, Nummela, Finland;School of Pharmacy, University of Eastern Finland, Kuopio, Finland)

机构地区：[1]Veterinary Clinic, Nummela, Finland [2]School of Pharmacy, University of Eastern Finland, Kuopio, Finland

出　　处：《Open Journal of Animal Sciences》2022年第1期129-144,共16页动物科学期刊（英文）

摘　　要：<span style="font-family:Verdana;">The most common allergic dermatitis of the horse is associated with hypersensitivity to insect bites. A purely hereditary-based background to this allergic pruritus has not been shown, and so far, it is not fully understood why some horses are more susceptible than others. Although altered zinc levels have been detected in many inflammatory and allergic disorders, changes in various trace elements have not been widely investigated in horses with allergic dermatitis. Therefore, the purpose was to analyse trace element profiles in the sera of 8 affected and 8 matched healthy horses and to further assess whether the profiles change after therapy of the affected animals. Sera were collected both before and after therapy of the eczema horses. Samples were analysed by inductively coupled plasma mass spectrometry for their iron (Fe), copper (Cu), zinc (Zn), titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), cobalt (Co) and nickel (Ni) content. Concentrations of Zn and Ni were significantly lower in eczema than in healthy horses (</span><i><i><span style="font-family:Verdana;">p</span></i><span></span></i><span><span style="font-family:Verdana;"> = 0.0089 and </span><i></i></span><i><i><span style="font-family:Verdana;">p</span></i><span></span></i><span style="font-family:Verdana;"> = 0.0018, respectively). In addition, concentrations of Fe, Zn and Ni displayed significant inverse associations with the severity of clinical signs (</span><i><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"></span></i><span style="font-family:Verdana;"> = 0.0075, <i></i></span><i><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"></span></i><span style="font-family:Verdana;"> = 0.0397 and <i></i></span><i><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"></span></i><span style="font-family:Verdana;"> = 0.0011, respectively). After a 4-week therapy, no significant differences were found between<span style="font-family:Verdana;">The most common allergic dermatitis of the horse is associated with hypersensitivity to insect bites. A purely hereditary-based background to this allergic pruritus has not been shown, and so far, it is not fully understood why some horses are more susceptible than others. Although altered zinc levels have been detected in many inflammatory and allergic disorders, changes in various trace elements have not been widely investigated in horses with allergic dermatitis. Therefore, the purpose was to analyse trace element profiles in the sera of 8 affected and 8 matched healthy horses and to further assess whether the profiles change after therapy of the affected animals. Sera were collected both before and after therapy of the eczema horses. Samples were analysed by inductively coupled plasma mass spectrometry for their iron (Fe), copper (Cu), zinc (Zn), titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), cobalt (Co) and nickel (Ni) content. Concentrations of Zn and Ni were significantly lower in eczema than in healthy horses (</span><i><i><span style="font-family:Verdana;">p</span></i><span></span></i><span><span style="font-family:Verdana;"> = 0.0089 and </span><i></i></span><i><i><span style="font-family:Verdana;">p</span></i><span></span></i><span style="font-family:Verdana;"> = 0.0018, respectively). In addition, concentrations of Fe, Zn and Ni displayed significant inverse associations with the severity of clinical signs (</span><i><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"></span></i><span style="font-family:Verdana;"> = 0.0075, <i></i></span><i><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"></span></i><span style="font-family:Verdana;"> = 0.0397 and <i></i></span><i><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"></span></i><span style="font-family:Verdana;"> = 0.0011, respectively). After a 4-week therapy, no significant differences were found between

关 键 词：Culicoides Equine Summer Eczema Insect Hypersensitivity Nickel Zinc 

分 类 号：R76[医药卫生—耳鼻咽喉科]