Prevalence of Extended-Spectrum Beta-Lactamase-Producing Strains Isolated at Zinder National Hospital (ZNH) in 2021 and Their Antibiotic Susceptibility Profile  

作　　者：Maman Sani Falissou Saïdou Abdoulaye Ousmane Abdoulaye Inoussa Abdoulaye Maman Bachir Hassane Boureima Lo Gora Alhousseini Maiga Daouda Doutchi Mahamadou Bako Saley Mahaman Laouali Sidi Maman Bacha Boukar Mamadou Saidou Maman Sani Falissou Saïdou;Abdoulaye Ousmane;Abdoulaye Inoussa;Abdoulaye Maman Bachir;Hassane Boureima;Lo Gora;Alhousseini Maiga Daouda;Doutchi Mahamadou;Bako Saley Mahaman Laouali;Sidi Maman Bacha Boukar;Mamadou Saidou(Faculté des Sciences de la Santé, Université Dan Dicko Dankoulodo de Maradi, Maradi, Niger;Hôpital National de Zinder, Zinder, Niger;Centre de Recherche Médicale et Sanitaire, Niamey, Niger;Faculté de Médecine, de Pharmacie et d’odontostomatologie, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal;Faculté des Sciences de la Santé, Université Abdou Moumouni, Niamey, Niger;Faculté des Sciences de la Santé, Université de Zinder, Zinder, Niger)

机构地区：[1]Faculté des Sciences de la Santé, Université Dan Dicko Dankoulodo de Maradi, Maradi, Niger [2]Hôpital National de Zinder, Zinder, Niger [3]Centre de Recherche Médicale et Sanitaire, Niamey, Niger [4]Faculté de Médecine, de Pharmacie et d’odontostomatologie, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal [5]Faculté des Sciences de la Santé, Université Abdou Moumouni, Niamey, Niger [6]Faculté des Sciences de la Santé, Université de Zinder, Zinder, Niger

出　　处：《Open Journal of Medical Microbiology》2023年第1期43-51,共9页医学微生物学（英文）

摘　　要：Purpose: Bacterial resistance to antibiotics has become a global public health problem. Enterobacteriaceae ESBL is among the most incriminated in this emergence which reduces the therapeutic possibilities. Thus, the objective of this study is to determine the prevalence of the extended-spectrum beta- lactamase (ESBL) producing Enterobacteriaceae at ZNH and their antibiotic susceptibility profile. Materials and Methods: This is a prospective study carried out over 5 months in all hospitalized and non-hospitalized patients in whom a culture was taken for the diagnosis of an infection. The search for ESBL is done by the double disc diffusion method. Results: In total, 21 out of 45 of our strains are ESBL-producing, i.e. a frequency of 46.7%. The mean age is 41.62 (±22.90) with extremes of 2.6 - 78 years. The distribution of ESBL producing species showed a predominance of E. coli with 66.7% followed by K. pneumoniae and K. oxytoca each 9.5%. All ESBL strains were resistant to Amoxicillin, Cefalotin, Pipiracillin, Piperacillin + tazobactam, Ticarcillin, Ticarcillin + clavulanic acid. Resistance to C3G and Aztreonam was each 95.5%, to Amoxicillin/clavulanic acid 9.1%. All strains were sensitive to imipenem. E. coli strains showed resistance: 85.7% to ciprofloxacin, 50% to Amikacin, 57.1% to Gentamicin. For K. pneumoniae, it is 66.7% for Gentamicin and Ciprofloxacin. Conclusion: Our study reports a high prevalence of ESBL at the HNZ. This must be taken into account in order to monitor this phenomenon which constitutes a public health problem. The study also reports sensitivity to Amoxicillin/clavulanic acid and Aminoside which can be an alternative.Purpose: Bacterial resistance to antibiotics has become a global public health problem. Enterobacteriaceae ESBL is among the most incriminated in this emergence which reduces the therapeutic possibilities. Thus, the objective of this study is to determine the prevalence of the extended-spectrum beta- lactamase (ESBL) producing Enterobacteriaceae at ZNH and their antibiotic susceptibility profile. Materials and Methods: This is a prospective study carried out over 5 months in all hospitalized and non-hospitalized patients in whom a culture was taken for the diagnosis of an infection. The search for ESBL is done by the double disc diffusion method. Results: In total, 21 out of 45 of our strains are ESBL-producing, i.e. a frequency of 46.7%. The mean age is 41.62 (±22.90) with extremes of 2.6 - 78 years. The distribution of ESBL producing species showed a predominance of E. coli with 66.7% followed by K. pneumoniae and K. oxytoca each 9.5%. All ESBL strains were resistant to Amoxicillin, Cefalotin, Pipiracillin, Piperacillin + tazobactam, Ticarcillin, Ticarcillin + clavulanic acid. Resistance to C3G and Aztreonam was each 95.5%, to Amoxicillin/clavulanic acid 9.1%. All strains were sensitive to imipenem. E. coli strains showed resistance: 85.7% to ciprofloxacin, 50% to Amikacin, 57.1% to Gentamicin. For K. pneumoniae, it is 66.7% for Gentamicin and Ciprofloxacin. Conclusion: Our study reports a high prevalence of ESBL at the HNZ. This must be taken into account in order to monitor this phenomenon which constitutes a public health problem. The study also reports sensitivity to Amoxicillin/clavulanic acid and Aminoside which can be an alternative.

关 键 词：Bacterial Resistance ESBL ENTEROBACTERIACEAE Zinder NIGER 

分 类 号：R44[医药卫生—诊断学]