Molecular Detection of Pathogens Involved in Sexually Transmitted Infections in Brazzaville, Congo  

作　　者：Jeanine Mireille Sita Maboundou Bitsi Nina Esther Ngoyi Ontsira Edith Sophie Kombo Bayonne Tanguy Mieret Geril Sekangue Obili Herlen Tsoumou Lina Foungou Kessengue Samantha Potokoue Mpia Chloé Dupont Guilhem Conquet Gickel Mpika Bitsene Bienvenu Roland Ibara Ossibi Axel Aloumba Etienne Nguimbi Sylvain Godreuil Jeanine Mireille Sita Maboundou Bitsi;Nina Esther Ngoyi Ontsira;Edith Sophie Kombo Bayonne;Tanguy Mieret;Geril Sekangue Obili;Herlen Tsoumou;Lina Foungou Kessengue;Samantha Potokoue Mpia;Chloé Dupont;Guilhem Conquet;Gickel Mpika Bitsene;Bienvenu Roland Ibara Ossibi;Axel Aloumba;Etienne Nguimbi;Sylvain Godreuil(Faculty of Sciences and Technology, Marien NGOUABI University, Brazzaville, Republic of the Congo;Faculty of Health Sciences, Marien NGOUABI University, Brazzaville, Republic of the Congo;Bacteriology-Virology Laboratory, University Hospital Center, Brazzaville, Republic of the Congo;Department of Infectious Diseases, Referral Hospital Center of Talanga, Brazzaville, Republic of the Congo;Parasitology-Mycology Laboratory, University Hospital Center, Brazzaville, Republic of the Congo;Department of Gynecology-Obstetrics, University Hospital Center, Brazzaville, Republic of the Congo;UMR IRD224-CNRS5290-UM MIVEGEC, Infectious Diseases and Vectors: Ecology, Genetics, Evolution and Control, CREES (Reshearch Center in Ecology and Evolution Health), Montpellier, France;Bacteriology Laboratory, Arnaud de Villeneuve University Hospital, CHU of Montpellier, Montpellier, France;Department of Infectious Diseases, University Hospital Center, Brazzaville, Republic of the Congo)

机构地区：[1]Faculty of Sciences and Technology, Marien NGOUABI University, Brazzaville, Republic of the Congo [2]Faculty of Health Sciences, Marien NGOUABI University, Brazzaville, Republic of the Congo [3]Bacteriology-Virology Laboratory, University Hospital Center, Brazzaville, Republic of the Congo [4]Department of Infectious Diseases, Referral Hospital Center of Talanga, Brazzaville, Republic of the Congo [5]Parasitology-Mycology Laboratory, University Hospital Center, Brazzaville, Republic of the Congo [6]Department of Gynecology-Obstetrics, University Hospital Center, Brazzaville, Republic of the Congo [7]UMR IRD224-CNRS5290-UM MIVEGEC, Infectious Diseases and Vectors: Ecology, Genetics, Evolution and Control, CREES (Reshearch Center in Ecology and Evolution Health), Montpellier, France [8]Bacteriology Laboratory, Arnaud de Villeneuve University Hospital, CHU of Montpellier, Montpellier, France [9]Department of Infectious Diseases, University Hospital Center, Brazzaville, Republic of the Congo

出　　处：《Open Journal of Medical Microbiology》2024年第3期190-205,共16页医学微生物学（英文）

摘　　要：The objective of this multicentric study was to assess the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma génitalium and Trichomonas vaginalis infections in Brazzaville, in the Republic of Congo, using molecular methods. From January to December 2021, the sexually transmitted disease risk participants were recruited from six centers: The Association of Young HIV-Positive People of Congo, The Congolese Association for Family Welfare, The Association for Support to Vulnerable Groups, Talangaï hospital, Brazzaville university hospital (outpatient service) and the private clinic COGEMO (outpatient service). The real-time multiplex PCR was carried out to detect these pathogens. Each patient had at least one specimen (urine, urethral, anal and/or vaginal samples). The patients were considered infected when one of their samples was positive. 287 participants made of 227 women and 60 men were tested. The general prevalence of these infections was: Chlamydia trachomatis 2.79%, Neisseria gonorrhoeae 3.14%, Mycoplasma génitalium 3.45% and Trichomonas vaginalis 2.97. The prevalence rates according to sex were: C. trachomatis, M. génitalium, N. gonorrhea and T. vaginalis were 1.32%, 2.05%, 1.32% and 3.42% in women and 8.33%, 7.02%, 10% and 1.75% in men, respectively. Most infected patients were asymptomatic. Prevalence rates were higher in bisexual individuals, with the exception of T. vaginalis which showed higher prevalence in heterosexual patients. The bisexual and homosexual individuals represent a major public health problem in sexually active young adults, particularly among men having sex with men. These sexually transmitted infections are mainly asymptomatic, their diagnosis and management remain difficult in developing countries.The objective of this multicentric study was to assess the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma génitalium and Trichomonas vaginalis infections in Brazzaville, in the Republic of Congo, using molecular methods. From January to December 2021, the sexually transmitted disease risk participants were recruited from six centers: The Association of Young HIV-Positive People of Congo, The Congolese Association for Family Welfare, The Association for Support to Vulnerable Groups, Talangaï hospital, Brazzaville university hospital (outpatient service) and the private clinic COGEMO (outpatient service). The real-time multiplex PCR was carried out to detect these pathogens. Each patient had at least one specimen (urine, urethral, anal and/or vaginal samples). The patients were considered infected when one of their samples was positive. 287 participants made of 227 women and 60 men were tested. The general prevalence of these infections was: Chlamydia trachomatis 2.79%, Neisseria gonorrhoeae 3.14%, Mycoplasma génitalium 3.45% and Trichomonas vaginalis 2.97. The prevalence rates according to sex were: C. trachomatis, M. génitalium, N. gonorrhea and T. vaginalis were 1.32%, 2.05%, 1.32% and 3.42% in women and 8.33%, 7.02%, 10% and 1.75% in men, respectively. Most infected patients were asymptomatic. Prevalence rates were higher in bisexual individuals, with the exception of T. vaginalis which showed higher prevalence in heterosexual patients. The bisexual and homosexual individuals represent a major public health problem in sexually active young adults, particularly among men having sex with men. These sexually transmitted infections are mainly asymptomatic, their diagnosis and management remain difficult in developing countries.

关 键 词：PREVALENCE Chlamydia trachomatis Neisseria gonorrhoeae Mycoplasma génitalium Trichomonas vaginalis 

分 类 号：R51[医药卫生—内科学]