Substituent effect on spectral and antimicrobial activity of Schiff bases derived from aminobenzoic acids  

作　　者：Felicia N. Ejiah Tolulope M. Fasina Oluwole B. Familoni Folashade T. Ogunsola 

机构地区：[1]Department of Chemistry, University of Lagos, Lagos, Nigeria [2]Department of Medical Microbiology, College of Medicine, University of Lagos, Lagos, Nigeria

出　　处：《Advances in Biological Chemistry》2013年第5期475-479,共5页生物化学进展（英文）

摘　　要：The dependence of electronic absorption spectra antimicrobial property on the substituent position was investigated using three Schiff bases derived from salicylaldehyde and isomeric aminobenzoic acids in three solvents of different polarities. The absorption maxima in all three solvents exhibited dependence on the position of substituent with the absorption maxima undergoing a red shift as solvent polarity increased. The in vitro antibacterial activity of the compounds against some clinically important bacteria namely Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 25923), Enterococcus feacalis (ATCC 29212) was determined in N,N”-dimethylformamide and 1,4-dioxane using the agar dilution method. The results revealed that the ortho and meta substituted Schiff bases exhibited better antimicrobial activity in the non-polar solvent.The dependence of electronic absorption spectra antimicrobial property on the substituent position was investigated using three Schiff bases derived from salicylaldehyde and isomeric aminobenzoic acids in three solvents of different polarities. The absorption maxima in all three solvents exhibited dependence on the position of substituent with the absorption maxima undergoing a red shift as solvent polarity increased. The in vitro antibacterial activity of the compounds against some clinically important bacteria namely Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 25923), Enterococcus feacalis (ATCC 29212) was determined in N,N”-dimethylformamide and 1,4-dioxane using the agar dilution method. The results revealed that the ortho and meta substituted Schiff bases exhibited better antimicrobial activity in the non-polar solvent.

关 键 词：SCHIFF Base Aminobenzoic ACID ANTIBACTERIAL Activity Salicyaldehyde Electronic SPECTRA 

分 类 号：O6[理学—化学]