Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds  

作　　者：Moraes Fabricio Tarso Galvão Anderson Dourado Fortaleza Dário Batista Amorin Kelly Aparecida da Encarnação Sousa Claudia Cristina Honorio-França Adenilda Cristina França Eduardo Luzia Costa Daniel Tizo Santos Wagner Batista Moraes Fabricio Tarso;Galvão Anderson Dourado;Fortaleza Dário Batista;Amorin Kelly Aparecida da Encarnação;Sousa Claudia Cristina;Honorio-França Adenilda Cristina;França Eduardo Luzia;Costa Daniel Tizo;Santos Wagner Batista(Institute of Exact Sciences and Earth, Federal University of Mato Grosso, Barra do Garcas/MT, Brazil;Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas/MT, Brazil;UniRv-University of Rio Verde, Rio Verde/Go, Brazil)

机构地区：[1]Institute of Exact Sciences and Earth, Federal University of Mato Grosso, Barra do Garcas/MT, Brazil [2]Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas/MT, Brazil [3]UniRv-University of Rio Verde, Rio Verde/Go, Brazil

出　　处：《Advances in Biological Chemistry》2020年第3期86-98,共13页生物化学进展（英文）

摘　　要：<span style="font-family:Verdana;">To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;">(bipy)] a route in a simple and reproducible synthesis for a novel compound of coordinating Ru</span>^{<span style="font-family:Verdana;">+3</span>}<span style="font-family:Verdana;"> with bipy and L-trip. The spectroscopic characterization in the mi</span><span style="font-family:Verdana;">ddle infrared region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the displacement of the carboxylate ion band for</span><span><span style="font-family:Verdana;"> higher energies, and also by the displacements of aliphatic amine bands, suggesting that bidentate coordination of the L-trip ligand occurred. Analysis of the results obtained with thermoanalytical techniques showed that the minimum formula of the compound, [RuCl</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">(bipy)(L-trip)]1/2H</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">O. Evaluation of the</span></span><span><span style="font-family:Verdana;"> antitumor potential of precursor K[RuCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;">(bipy)] showed the toxic effects on MCF-7 cell line, but </span></span><span style="font-family:Verdana;">did not show selectivity and not reached PBMC cells to the same extent. The evaluation of the antitumor potential of the newly synthesized compound, [RuCl</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">(bipy)(L-trip)], demonstrated that the insertion of an L-tryptophan molecule into the precursor coordination sphere made it selective when compared to PBMC cells, for MCF-7 type tumor cells.</span><span style="font-family:Verdana;">To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;">(bipy)] a route in a simple and reproducible synthesis for a novel compound of coordinating Ru</span>^{<span style="font-family:Verdana;">+3</span>}<span style="font-family:Verdana;"> with bipy and L-trip. The spectroscopic characterization in the mi</span><span style="font-family:Verdana;">ddle infrared region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the displacement of the carboxylate ion band for</span><span><span style="font-family:Verdana;"> higher energies, and also by the displacements of aliphatic amine bands, suggesting that bidentate coordination of the L-trip ligand occurred. Analysis of the results obtained with thermoanalytical techniques showed that the minimum formula of the compound, [RuCl</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">(bipy)(L-trip)]1/2H</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">O. Evaluation of the</span></span><span><span style="font-family:Verdana;"> antitumor potential of precursor K[RuCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;">(bipy)] showed the toxic effects on MCF-7 cell line, but </span></span><span style="font-family:Verdana;">did not show selectivity and not reached PBMC cells to the same extent. The evaluation of the antitumor potential of the newly synthesized compound, [RuCl</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">(bipy)(L-trip)], demonstrated that the insertion of an L-tryptophan molecule into the precursor coordination sphere made it selective when compared to PBMC cells, for MCF-7 type tumor cells.</span>

关 键 词：Ruthenium Compounds Pyridine Ligands Antitumor Activity Tryptophan Amino Acid MCF-7 Cells Ligand N-Heterocyclic 

分 类 号：O62[理学—有机化学]