Synthesis, Characterization and Antibacterial Activities of Polydentate Schiff Bases, Based on Salicylaldehyde  

作　　者：Yosef Bayeh Fekiya Mohammed Mamo Gebrezgiabher Fikre Elemo Mesfin Getachew Madhu Thomas Yosef Bayeh;Fekiya Mohammed;Mamo Gebrezgiabher;Fikre Elemo;Mesfin Getachew;Madhu Thomas(Department of Industrial Chemistry, College of Applied Sciences, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia;Center of Excellence in Nanotechnology, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia;Department of Food Engineering, College of Biological and Chemical Engineering, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia)

机构地区：[1]Department of Industrial Chemistry, College of Applied Sciences, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia [2]Center of Excellence in Nanotechnology, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia [3]Department of Food Engineering, College of Biological and Chemical Engineering, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia

出　　处：《Advances in Biological Chemistry》2020年第5期127-139,共13页生物化学进展（英文）

摘　　要：<span style="font-family:Verdana;">Three Schiff bases L</span>_{<span style="font-family:Verdana;">1</span>}<span style="font-family:Verdana;">, L</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;"> and L</span>_{<span style="font-family:Verdana;">3</span>}<span style="font-family:Verdana;"> were synthesized by condensing salicylalde</span><span style="font-family:Verdana;">hyde with 4-aminoantipyrine, ethylendiamine and 2-aminophenol respec</span><span style="font-family:Verdana;">tively and subsequently characterized by various physicochemical investigations. All the three compounds were screened for their </span><i><span style="font-family:Verdana;">In-vitro</span></i><span style="font-family:Verdana;"> antibacterial activity against two gram positive bacteria, </span><i><span style="font-family:Verdana;">Staphylococcus aureus</span></i><span style="font-family:Verdana;"> (S.A), </span><i><span style="font-family:Verdana;">Staphylococcus epidermidis</span></i><span style="font-family:Verdana;"> (S.E) and two gram negative bacteria </span><i><span style="font-family:Verdana;">Klebsiella</span></i><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">pneumoniae</span></i></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> (K.P) and </span><i><span style="font-family:Verdana;">Pseudomonas aeruginosa </span></i><span style="font-family:Verdana;">(</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">P.</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">A) by agar diffusion method. On comparing the results obtained with the activity of commercially available antibiotics such as Ciprofloxacin and Chloramphenicol, the newly synthesized compounds showed comparable antibacterial ac<span style="font-family:Verdana;">Three Schiff bases L</span>_{<span style="font-family:Verdana;">1</span>}<span style="font-family:Verdana;">, L</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;"> and L</span>_{<span style="font-family:Verdana;">3</span>}<span style="font-family:Verdana;"> were synthesized by condensing salicylalde</span><span style="font-family:Verdana;">hyde with 4-aminoantipyrine, ethylendiamine and 2-aminophenol respec</span><span style="font-family:Verdana;">tively and subsequently characterized by various physicochemical investigations. All the three compounds were screened for their </span><i><span style="font-family:Verdana;">In-vitro</span></i><span style="font-family:Verdana;"> antibacterial activity against two gram positive bacteria, </span><i><span style="font-family:Verdana;">Staphylococcus aureus</span></i><span style="font-family:Verdana;"> (S.A), </span><i><span style="font-family:Verdana;">Staphylococcus epidermidis</span></i><span style="font-family:Verdana;"> (S.E) and two gram negative bacteria </span><i><span style="font-family:Verdana;">Klebsiella</span></i><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">pneumoniae</span></i></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> (K.P) and </span><i><span style="font-family:Verdana;">Pseudomonas aeruginosa </span></i><span style="font-family:Verdana;">(</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">P.</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">A) by agar diffusion method. On comparing the results obtained with the activity of commercially available antibiotics such as Ciprofloxacin and Chloramphenicol, the newly synthesized compounds showed comparable antibacterial ac

关 键 词：Schiff Bases Salicyaldehyde Antibacterial Activity In-Vitro 

分 类 号：O17[理学—数学]