Synthesis, Characterization, Antimicrobial and DNA Binding Studies of a Tetradentate N2O2 Amino Acid Schiff Base and Its Coordination Compounds  

作　　者：Temitayo O. Aiyelabola Daniel P. Otto Johan H. L. Jordaan Ezekiel O. Akinkunmi Idowu Olawuni Temitayo O. Aiyelabola;Daniel P. Otto;Johan H. L. Jordaan;Ezekiel O. Akinkunmi;Idowu Olawuni(Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria;Research Focus Area for Chemical Resource Beneficiation, Laboratory for Analytical Services, North-West University, Potchefstroom, South Africa;Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria;Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria)

机构地区：[1]Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria [2]Research Focus Area for Chemical Resource Beneficiation, Laboratory for Analytical Services, North-West University, Potchefstroom, South Africa [3]Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria [4]Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria

出　　处：《Advances in Biological Chemistry》2021年第1期30-51,共22页生物化学进展（英文）

摘　　要：<span style="font-family:Verdana;">Aminoethanoic acid undergoes condensation with 1,4-benzenedicarboxaldehyde</span><span><span><span style="font-family:""><span style="font-family:Verdana;"> to form an O, N, N, O donor Schiff base, </span><i><span style="font-family:Verdana;">N,N'</span></i><span style="font-family:Verdana;">-di(carboxymethylene)</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">terephthalaldehyde, Ligand L. Coordination compounds of this Schiff base us</span><span><span style="font-family:Verdana;">ing Ni (II), Cu (II), </span><span style="font-family:Verdana;">VO</span><span style="font-family:Verdana;"> (IV) and Co (II) were then obtained </span><i><span style="font-family:Verdana;">in-situ</span></i><span style="font-family:Verdana;">. The</span></span><span style="font-family:Verdana;"> Schiff base and the complexes were evaluated for their antimicrobial and DNA binding abilities. Molecular docking studies of the ligand and synthesized compounds were also carried out. Evidence for the formation of the Schiff base coordination compounds and the coordinating atoms was obtained from </span>^{<span style="font-family:Verdana;">1</span>}<span style="font-family:Verdana;">H NMR, infrared and ultraviolet spectral data, EDX, EDTA complexometric titration and magnetic susceptibility measurement. The results obtained are consistent with octahedral geometry for Ni (II) complex</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> the metal ion coordinating to one molecule of Ligand L</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> and</span></span></span><span style="font-family:Verdana;"><span style="f<span style="font-family:Verdana;">Aminoethanoic acid undergoes condensation with 1,4-benzenedicarboxaldehyde</span><span><span><span style="font-family:""><span style="font-family:Verdana;"> to form an O, N, N, O donor Schiff base, </span><i><span style="font-family:Verdana;">N,N'</span></i><span style="font-family:Verdana;">-di(carboxymethylene)</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">terephthalaldehyde, Ligand L. Coordination compounds of this Schiff base us</span><span><span style="font-family:Verdana;">ing Ni (II), Cu (II), </span><span style="font-family:Verdana;">VO</span><span style="font-family:Verdana;"> (IV) and Co (II) were then obtained </span><i><span style="font-family:Verdana;">in-situ</span></i><span style="font-family:Verdana;">. The</span></span><span style="font-family:Verdana;"> Schiff base and the complexes were evaluated for their antimicrobial and DNA binding abilities. Molecular docking studies of the ligand and synthesized compounds were also carried out. Evidence for the formation of the Schiff base coordination compounds and the coordinating atoms was obtained from </span>^{<span style="font-family:Verdana;">1</span>}<span style="font-family:Verdana;">H NMR, infrared and ultraviolet spectral data, EDX, EDTA complexometric titration and magnetic susceptibility measurement. The results obtained are consistent with octahedral geometry for Ni (II) complex</span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> the metal ion coordinating to one molecule of Ligand L</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> and</span></span></span><span style="font-family:Verdana;"><span style="f

关 键 词：CT-DNA DNA Binding ANTIMICROBIAL Coordination Compound Molecular Docking Schiff Base 

分 类 号：O62[理学—有机化学]