<i>Fusarium lini</i>Potential for the Biotransformation of Norandrostenedione and Evaluation of Urease and Chymotrypsin Properties of the Transformed Products  

作　　者：Simeon Pierre Chegaing Fodouop Alex Doris Kengni Mboussaah Didiane Yemele Mefokou Alain Bertrand Fowa Mahwish Siddiqui Gabriel T. Kamsu Donatien Gatsing Muhammad Iqbal Choudhary Simeon Pierre Chegaing Fodouop;Alex Doris Kengni Mboussaah;Didiane Yemele Mefokou;Alain Bertrand Fowa;Mahwish Siddiqui;Gabriel T. Kamsu;Donatien Gatsing;Muhammad Iqbal Choudhary(Research Unit of Metabolic and Infectious Diseases, Department of Biomedical Sciences, Faculty of Science, University of Ngaoundéré, Ngaoundéré, Cameroon;H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;Research Unit of Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan)

机构地区：[1]Research Unit of Metabolic and Infectious Diseases, Department of Biomedical Sciences, Faculty of Science, University of Ngaoundéré, Ngaoundéré, Cameroon [2]H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan [3]Research Unit of Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon [4]Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon [5]International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

出　　处：《Advances in Biological Chemistry》2021年第2期65-77,共13页生物化学进展（英文）

摘　　要：<span style="font-family:Verdana;">Several androgenic steroids have been biotransformed by fungi into metabolites with numerous biological properties. Incubation of norandrostenedione (</span><b><span style="font-family:Verdana;">1</span></b><span style="font-family:Verdana;">) with </span><i><span style="font-family:Verdana;">Fusarium lini</span></i><span> </span><span style="font-family:Verdana;">NRRL 2204 was carried out for the first time, yielding two new metabolites, 3,7</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-dihydroxy-19-norandrost-1,3,5-trien-17-one</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(</span><b><span style="font-family:Verdana;">3</span></b><span style="font-family:Verdana;">) and 6</span><i><span style="font-family:Verdana;">α</span></i></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">10</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-trihydroxy-19-nor-4-androsten-3-one</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(</span><b><span style="font-family:Verdana;">4</span></b><span style="font-family:Verdana;">), along</span></span><span style="font-family:Verdana;"> with three known compounds, </span><span style="font-family:""><span style="font-family:Verdana;">3</span><b><span style="font-family:Verdana;">-</span></b><span style="font-family:Verdana;">hydroxy-19-norandrost-1,3,5-trien-17-one (</span><b><span style="font-family:Verdana;">2</span></b><span style="font-family:Verdana;">), 10</span></span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:""><span style="font-family:Verdana;">,</span><i> </i></span><span style="font-family:Verdana;">17</span><i><span style="font-family:Ver<span style="font-family:Verdana;">Several androgenic steroids have been biotransformed by fungi into metabolites with numerous biological properties. Incubation of norandrostenedione (</span><b><span style="font-family:Verdana;">1</span></b><span style="font-family:Verdana;">) with </span><i><span style="font-family:Verdana;">Fusarium lini</span></i><span> </span><span style="font-family:Verdana;">NRRL 2204 was carried out for the first time, yielding two new metabolites, 3,7</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-dihydroxy-19-norandrost-1,3,5-trien-17-one</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(</span><b><span style="font-family:Verdana;">3</span></b><span style="font-family:Verdana;">) and 6</span><i><span style="font-family:Verdana;">α</span></i></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">10</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;">17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-trihydroxy-19-nor-4-androsten-3-one</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">(</span><b><span style="font-family:Verdana;">4</span></b><span style="font-family:Verdana;">), along</span></span><span style="font-family:Verdana;"> with three known compounds, </span><span style="font-family:""><span style="font-family:Verdana;">3</span><b><span style="font-family:Verdana;">-</span></b><span style="font-family:Verdana;">hydroxy-19-norandrost-1,3,5-trien-17-one (</span><b><span style="font-family:Verdana;">2</span></b><span style="font-family:Verdana;">), 10</span></span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:""><span style="font-family:Verdana;">,</span><i> </i></span><span style="font-family:Verdana;">17</span><i><span style="font-family:Ver

关 键 词：Chymotrypsin Inhibition Norandrostenedione Fusarium lini Urease Inhibition 

分 类 号：O17[理学—数学]