Triterpenoids and Semisynthetic Derivatives with Antimicrobial Activities from the Leaves of <i>Caloncoba glauca</i>(Flacourtiaceae)  

作　　者：James D. Simo Mpetga Arno R. Nanfack Donfack Jean-De-Dieu Tamokou Irene Chinda Kengne Pierre Tane Xiao-Jiang Hao Mathieu Tene James D. Simo Mpetga;Arno R. Nanfack Donfack;Jean-De-Dieu Tamokou;Irene Chinda Kengne;Pierre Tane;Xiao-Jiang Hao;Mathieu Tene(Natural Products Chemistry Research Unit, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China)

机构地区：[1]Natural Products Chemistry Research Unit, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon [2]Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon [3]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China

出　　处：《Advances in Biological Chemistry》2021年第4期149-164,共16页生物化学进展（英文）

摘　　要：<span style="font-family:Verdana;">Chemical investigation of the MeOH extract from the leaves of </span><i><span style="font-family:Verdana;">C.</span></i> <i><span style="font-family:Verdana;">glauca</span></i> <span><span style="font-family:Verdana;">yielded nine known triterpenoids (</span><b><span style="font-family:Verdana;">1-9</span></b><span style="font-family:Verdana;">) belonging to the cycloartane and</span></span><span style="font-family:Verdana;"> friedelane series. Two of these compounds namely glaucartanoic acid A (</span><b><span style="font-family:Verdana;">1</span></b><span style="font-family:Verdana;">) and 3</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">,21</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-dihydroxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic acid (</span><b><span style="font-family:Verdana;">5</span></b><span style="font-family:Verdana;">) were subjected to chemical derivatizations and afforded five new derivatives: diacetylglaucartanoic acid A (</span><b><span style="font-family:Verdana;">1a</span></b><span style="font-family:Verdana;">), 24-acetylglaucartanoic acid A (</span><b><span style="font-family:Verdana;">1b</span></b><span style="font-family:Verdana;">), glaucartanoic acid A methyl ester (</span><b><span style="font-family:Verdana;">1c</span></b><span style="font-family:Verdana;">), 24-methoxyglaucartanoic acid A methyl </span><span><span style="font-family:Verdana;">ester (</span><b><span style="font-family:Verdana;">1d</span></b><span style="font-family:Verdana;">), and 3</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">,21</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-diacetoxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic</span></span><span style="font-family:Verdana;"> acid (</span><b><span style="font-family:Verdana;">5a</span></b><span style="font-family:Verdana;">). Their structures were <span style="font-family:Verdana;">Chemical investigation of the MeOH extract from the leaves of </span><i><span style="font-family:Verdana;">C.</span></i> <i><span style="font-family:Verdana;">glauca</span></i> <span><span style="font-family:Verdana;">yielded nine known triterpenoids (</span><b><span style="font-family:Verdana;">1-9</span></b><span style="font-family:Verdana;">) belonging to the cycloartane and</span></span><span style="font-family:Verdana;"> friedelane series. Two of these compounds namely glaucartanoic acid A (</span><b><span style="font-family:Verdana;">1</span></b><span style="font-family:Verdana;">) and 3</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">,21</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-dihydroxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic acid (</span><b><span style="font-family:Verdana;">5</span></b><span style="font-family:Verdana;">) were subjected to chemical derivatizations and afforded five new derivatives: diacetylglaucartanoic acid A (</span><b><span style="font-family:Verdana;">1a</span></b><span style="font-family:Verdana;">), 24-acetylglaucartanoic acid A (</span><b><span style="font-family:Verdana;">1b</span></b><span style="font-family:Verdana;">), glaucartanoic acid A methyl ester (</span><b><span style="font-family:Verdana;">1c</span></b><span style="font-family:Verdana;">), 24-methoxyglaucartanoic acid A methyl </span><span><span style="font-family:Verdana;">ester (</span><b><span style="font-family:Verdana;">1d</span></b><span style="font-family:Verdana;">), and 3</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">,21</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-diacetoxy-30-nor-(D:A)-friedoolean-20(29)-en-27-oic</span></span><span style="font-family:Verdana;"> acid (</span><b><span style="font-family:Verdana;">5a</span></b><span style="font-family:Verdana;">). Their structures were

关 键 词：Caloncoba glauca TRITERPENOIDS Chemical Derivatizations Antimicrobial Activity Structure-Activity Relationship 

分 类 号：O17[理学—数学]