Influence of Haptoglobin and Hemoglobin Phenotypic Polymorphisms on Sickle Cell Disease Morbidity  

作　　者：Hugues Ahiboh Akissi Joelle Koffi Aniéla Kanga Philemond By Fatoumata Koné Hermance Kassi Francisk Kouakou Marie-Laure Hauhouot-Attoungbré Duni Sawadogo Hugues Ahiboh;Akissi Joelle Koffi;Aniéla Kanga;Philemond By;Fatoumata Koné;Hermance Kassi;Francisk Kouakou;Marie-Laure Hauhouot-Attoungbré;Duni Sawadogo(Biochemistry and Clinical Chemistry Unit, CeDReS, University Hospital of Treichville, Abidjan, Ivory Coast;Department of Hematology, University Hospital of Bouaké, Bouaké, Ivory Coast;Molecular Biology Unit, CeDReS, University Hospital of Treichville, Abidjan, Ivory Coast;Hematology Unit, CeDReS, University Hospital of Treichville, Abidjan, Ivory Coast;Department of Biochemistry, Clinical Chemistry and Molecular Biology, Faculty of Pharmaceutical and Biological Sciences, University Felix Houphouet-Boigny, Abidjan, Ivory Coast;Department of Hematology and Cell Biology, Faculty of Pharmaceutical and Biological Sciences, University Felix Houphouet-Boigny, Abidjan, Ivory Coast)

机构地区：[1]Biochemistry and Clinical Chemistry Unit, CeDReS, University Hospital of Treichville, Abidjan, Ivory Coast [2]Department of Hematology, University Hospital of Bouaké, Bouaké, Ivory Coast [3]Molecular Biology Unit, CeDReS, University Hospital of Treichville, Abidjan, Ivory Coast [4]Hematology Unit, CeDReS, University Hospital of Treichville, Abidjan, Ivory Coast [5]Department of Biochemistry, Clinical Chemistry and Molecular Biology, Faculty of Pharmaceutical and Biological Sciences, University Felix Houphouet-Boigny, Abidjan, Ivory Coast [6]Department of Hematology and Cell Biology, Faculty of Pharmaceutical and Biological Sciences, University Felix Houphouet-Boigny, Abidjan, Ivory Coast

出　　处：《Advances in Biological Chemistry》2023年第5期171-181,共11页生物化学进展（英文）

摘　　要：Objectives: Sickle cell disease (SCD) has a varied clinical and biological expression depending on the hemoglobin phenotype: SSFA₂, SFA₂, SAFA₂ and SC. Considering the antioxidant properties of the different haptoglobin phenotypes (Hp 1-1, Hp 2-1, Hp 2-2), it seemed relevant to know their influence on the morbidity of the different hemoglobin phenotype of SCD. Thus, the objective of this study was to identify associations between haptoglobin phenotype and morbidity of different SCD phenotypes. Methods: In a retrospective cross-sectional descriptive and analytical study, with a cohort of 170 black African carriers of hemoglobin S, in Ivory Coast, West Africa, hemoglobin and haptoglobin phenotypes were determined by electrophoretic methods. Results: The three major phenotypes of haptoglobin polymorphism were found in the SCD cohort: Hp 1-1 (24.1%), Hp 2-1 (56.5%), Hp 2-2 (19.4%). Vaso-occlusions were associated with haptoglobin phenotype Hp 1-1, (OR = 2.03;CI_95% = [1.06 - 3.9];p Conclusions: Haptoglobin phenotype was associated to morbidity-adjusted hemoglobin phenotype. The study revealed a greater probability of a worse morbidity when the hemoglobin phenotype is homozygous. Unexpectedly, the worse morbidity is associated to Hp 1-1 haptoglobin phenotype, the most powerful antioxidant within the different haptoglobin phenotypes. Associations found were not systematic and need further studies to enlighten the determinism of SCD morbidity.Objectives: Sickle cell disease (SCD) has a varied clinical and biological expression depending on the hemoglobin phenotype: SSFA₂, SFA₂, SAFA₂ and SC. Considering the antioxidant properties of the different haptoglobin phenotypes (Hp 1-1, Hp 2-1, Hp 2-2), it seemed relevant to know their influence on the morbidity of the different hemoglobin phenotype of SCD. Thus, the objective of this study was to identify associations between haptoglobin phenotype and morbidity of different SCD phenotypes. Methods: In a retrospective cross-sectional descriptive and analytical study, with a cohort of 170 black African carriers of hemoglobin S, in Ivory Coast, West Africa, hemoglobin and haptoglobin phenotypes were determined by electrophoretic methods. Results: The three major phenotypes of haptoglobin polymorphism were found in the SCD cohort: Hp 1-1 (24.1%), Hp 2-1 (56.5%), Hp 2-2 (19.4%). Vaso-occlusions were associated with haptoglobin phenotype Hp 1-1, (OR = 2.03;CI_95% = [1.06 - 3.9];p Conclusions: Haptoglobin phenotype was associated to morbidity-adjusted hemoglobin phenotype. The study revealed a greater probability of a worse morbidity when the hemoglobin phenotype is homozygous. Unexpectedly, the worse morbidity is associated to Hp 1-1 haptoglobin phenotype, the most powerful antioxidant within the different haptoglobin phenotypes. Associations found were not systematic and need further studies to enlighten the determinism of SCD morbidity.

关 键 词：Haptoglobin Phenotype Hemoglobin Phenotype Sickle Cell Disease MORBIDITY 

分 类 号：R54[医药卫生—心血管疾病]