Synthesis and Guest-Binding Behavior of Water-Soluble Cyclophanes Bearing PEG Residues  

作　　者：Osamu Hayashida Yuki Nakamura Takuya Sato 

机构地区：[1]Department of Chemistry, Faculty of Science, Fukuoka University, Fukuoka, Japan

出　　处：《Advances in Chemical Engineering and Science》2014年第4期409-416,共8页化学工程与科学期刊（英文）

摘　　要：A water-soluble cyclophane (1) having poly(ethylene glycol) (PEG) moieties has been prepared from a tetraazide-functionalized cyclophane derivative and four poly(ethylene glycol) methyl ether acetylenes by Cu(I)-catalyzed 1,3 dipolar cycloadditions (click chemistry). An analogous derivative having a pyrene moiety (2) was also prepared in a similar manner. The guest-binding behavior of 1 and 2 toward anionic guests such as 6-p-toluidinonaphthalene-2-sulfonate was investigated by fluorescence spectroscopy. The binding constants (K) of the host-guest complexes were evaluated.A water-soluble cyclophane (1) having poly(ethylene glycol) (PEG) moieties has been prepared from a tetraazide-functionalized cyclophane derivative and four poly(ethylene glycol) methyl ether acetylenes by Cu(I)-catalyzed 1,3 dipolar cycloadditions (click chemistry). An analogous derivative having a pyrene moiety (2) was also prepared in a similar manner. The guest-binding behavior of 1 and 2 toward anionic guests such as 6-p-toluidinonaphthalene-2-sulfonate was investigated by fluorescence spectroscopy. The binding constants (K) of the host-guest complexes were evaluated.

关 键 词：HOST-GUEST Chemistry WATER-SOLUBLE CYCLOPHANE Poly(Ethylene Glycol) 

分 类 号：O6[理学—化学]