Solventless Organic Reactive Crystallization at Mild Conditions  

作　　者：Masaaki Yokota Norihito Doki Hiroyuki Akagaki 

机构地区：[1]Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan

出　　处：《Advances in Chemical Engineering and Science》2015年第4期461-464,共4页化学工程与科学期刊（英文）

摘　　要：Solid state mixtures of two reactants, 2-hydroxy-1-naphthaldehyde and 2-aminobenzonitrile, were melted at a temperature even lower than both the melting points. And dehydration condensation reaction occurred in the melt to give reaction product N-(2-cyanophenyl)-2-hydroxy-1-naphthadimine. Since the melting point of the product was higher than the reactants, self-crystallization of the product occurred. Usefulness of this one-pot synthesis and crystallization method for industrial application was described.Solid state mixtures of two reactants, 2-hydroxy-1-naphthaldehyde and 2-aminobenzonitrile, were melted at a temperature even lower than both the melting points. And dehydration condensation reaction occurred in the melt to give reaction product N-(2-cyanophenyl)-2-hydroxy-1-naphthadimine. Since the melting point of the product was higher than the reactants, self-crystallization of the product occurred. Usefulness of this one-pot synthesis and crystallization method for industrial application was described.

关 键 词：Reaction CRYSTALLIZATION POLYMORPHISM DEHYDRATION CONDENSATION 

分 类 号：O6[理学—化学]