Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach  

作　　者：Arunkanth Krishnakumar Nair Peddakotla Venkata Ramana P. Venkat Bhaskar Rao Bapatu Hanimi Reddy Hari Kishan Reddy Ganthi Useni Reddy Mallu 

机构地区：[1]Sri Krishnadevaraya University, Anantapur, India [2]Jawaharlal Nehru Technological University, Hyderabad, India

出　　处：《American Journal of Analytical Chemistry》2017年第3期189-209,共21页美国分析化学（英文）

摘　　要：The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.

关 键 词：ATORVASTATIN Calcium Tablets Controlled RELEASE CARBOMER RELEASE Controlling Polymer GELLING Agent POVIDONE 

分 类 号：R9[医药卫生—药学]