Determination of Lisinopril in Bulk and Pharmaceutical Formulations by Cloud Point Extraction—A Green Method  

作　　者：V. Mallikarjuna Sarma N. V. S. Venugopal L. Giribabu V. Mallikarjuna Sarma;N. V. S. Venugopal;L. Giribabu(Department of Chemistry, P. R. Government College (A), Kakinada, Andhrapradesh, India;Department of Chemistry, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India;Indian Institute of Chemical Technology, Hyderabad, Telangana, India)

机构地区：[1]Department of Chemistry, P. R. Government College (A), Kakinada, Andhrapradesh, India [2]Department of Chemistry, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, India [3]Indian Institute of Chemical Technology, Hyderabad, Telangana, India

出　　处：《American Journal of Analytical Chemistry》2020年第8期289-300,共12页美国分析化学（英文）

摘　　要：<span style="font-family:Verdana;">A sensitive and eco-friendly method was developed for the spectrophotometric determination of Lisinopril (LSP) in bulk and pharmaceutical formulations by cloud point extraction technique. The method was based on the formation of a blue</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">colored coordination complex between Lisinopril (LSP) and Cobalt Thiocyanate (CTC) at a suitable pH.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The Complex in aqueous medium</span><span style="font-family:Verdana;"> was extracted into surfactant layer by cloud point extraction using</span><span style="font-family:Verdana;"> a non-ionic surfactant Triton X-114 and then the surfactant layer was dissolved in a suitable volume of ethanol and the amount of Lisinopril was determined spectrophotometrically at a wavelength of 625</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">nm.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The conditions like concentration of the drug, concentration of CTC and of Triton X-114, P</span>^{<span style="font-family:Verdana;">H</span>}</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> etc. were optimized by OFAT (One Factor At a Time) method. The linear range of calibration curve was 1</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">6 μg/ml and the linear regression equation with a correlation coefficient of 0.99996 was y = 0.0021</span><span style="font-family:""> </span><span style="font-family:Verdana;">+</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.084x.</span><span style="font-family:""> </span><span style="font-family:Verdana;">Preconcentration and enrichment factors were found to be 100 and 3.12 re<span style="font-family:Verdana;">A sensitive and eco-friendly method was developed for the spectrophotometric determination of Lisinopril (LSP) in bulk and pharmaceutical formulations by cloud point extraction technique. The method was based on the formation of a blue</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">colored coordination complex between Lisinopril (LSP) and Cobalt Thiocyanate (CTC) at a suitable pH.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The Complex in aqueous medium</span><span style="font-family:Verdana;"> was extracted into surfactant layer by cloud point extraction using</span><span style="font-family:Verdana;"> a non-ionic surfactant Triton X-114 and then the surfactant layer was dissolved in a suitable volume of ethanol and the amount of Lisinopril was determined spectrophotometrically at a wavelength of 625</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">nm.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The conditions like concentration of the drug, concentration of CTC and of Triton X-114, P</span>^{<span style="font-family:Verdana;">H</span>}</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> etc. were optimized by OFAT (One Factor At a Time) method. The linear range of calibration curve was 1</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">6 μg/ml and the linear regression equation with a correlation coefficient of 0.99996 was y = 0.0021</span><span style="font-family:""> </span><span style="font-family:Verdana;">+</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.084x.</span><span style="font-family:""> </span><span style="font-family:Verdana;">Preconcentration and enrichment factors were found to be 100 and 3.12 re

关 键 词：Lisinopril (LSP) Cobalt Thiocyanate (CTC) Coordination Complex Formation Cloud Pint Extraction (CPE) SPECTROPHOTOMETRY 

分 类 号：O17[理学—数学]