Synthesis and Charcterization of Silane Crosslinked Hydrogel to pH Sensitive Study  

作　　者：Muhammad Awais Shahid Abdul Haseeb Tahir Zeeshan Ahmad Muhammad Arslan Muhammad Awais Shahid;Abdul Haseeb Tahir;Zeeshan Ahmad;Muhammad Arslan(Department of Physics, The University of Lahore, Lahore, Punjab, Pakistan;Department of Chemistry, Minhaj University Lahore, Lahore, Pakistan;Department of Physics, University of Punjab, Lahore, Pakistan)

机构地区：[1]Department of Physics, The University of Lahore, Lahore, Punjab, Pakistan [2]Department of Chemistry, Minhaj University Lahore, Lahore, Pakistan [3]Department of Physics, University of Punjab, Lahore, Pakistan

出　　处：《American Journal of Analytical Chemistry》2024年第5期165-176,共12页美国分析化学（英文）

摘　　要：Eco-friendly and biodegradable novel hydrogel were prepared by blending and solution casting method. The designed hydrogel is based on chitosan/ PEG600/Gurgam with carbon nanofiller along silane crosslinked (TEOS) with pH sensitive response to controlled release of drug in biomedical materials and agriculture industry. The various concentration of carbon nanofiller is used to analyze its effect on the fabricated hydrogel characteristics by using FTIR, SEM, TGA, swelling studies (water, buffer and ionic solution). Spectra of FTIR reflected both established and newly developed groups (like hydrogel). COOH group presence is clearly observed in this range in the carbon filler reinforced hydrogel. The SEM micrographs show that CPG0.003 had a collection of polysaccharide chains as thin helices, which is attributed to the increase in the size of porosity. TGA shows to increase concentration of nanofiller enhanced the thermal stability of the designed hydrogels at temperature 25˚C to 550˚C mass loss percentage decrease upto 20% and increase thermal stability. This pH response made these resultant hydrogels as fruitful competitor against the many reported controlled release application.Eco-friendly and biodegradable novel hydrogel were prepared by blending and solution casting method. The designed hydrogel is based on chitosan/ PEG600/Gurgam with carbon nanofiller along silane crosslinked (TEOS) with pH sensitive response to controlled release of drug in biomedical materials and agriculture industry. The various concentration of carbon nanofiller is used to analyze its effect on the fabricated hydrogel characteristics by using FTIR, SEM, TGA, swelling studies (water, buffer and ionic solution). Spectra of FTIR reflected both established and newly developed groups (like hydrogel). COOH group presence is clearly observed in this range in the carbon filler reinforced hydrogel. The SEM micrographs show that CPG0.003 had a collection of polysaccharide chains as thin helices, which is attributed to the increase in the size of porosity. TGA shows to increase concentration of nanofiller enhanced the thermal stability of the designed hydrogels at temperature 25˚C to 550˚C mass loss percentage decrease upto 20% and increase thermal stability. This pH response made these resultant hydrogels as fruitful competitor against the many reported controlled release application.

关 键 词：CHITOSAN Guargum HYDROGEL Carbon Nano Filler Silane Cross Linker pH Sensitive 

分 类 号：O63[理学—高分子化学]