Synthesis and Crystal Structure Studies of Mitomycin C Dihydrate  

作　　者：Yingqi Feng Yongshou Chen Yixin Ren Heng Zhang Shuang Cao 

机构地区：[1]Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, China

出　　处：《Crystal Structure Theory and Applications》2020年第2期13-21,共9页晶体结构理论与应用（英文）

摘　　要：The absolute configuration of mitomycin C was determined?by X-ray single crystal diffraction?(CuKα), and a new?crystalline?dihydrate of mitomycin C had been prepared. The?experiment?result?provides?a definitive answer?to the real absolute configuration of mitomycin C and may put an end to the dispute?that baffles?researchers for decades.?At the same time, some contentious structures?about the mitomycin C in?American Pharmacopoeia?USP36-NF31,?Chinese pharmacopoeia?2015?edtion?and numbers of?literatures are marked. The absolute configuration?is?also verified?by?1D (1H?and?13C) and 2D (HSQC, HMBC,?1H-1H?COSY?and?NOESY) NMR studies?indirectly. Powder X-ray diffraction (PXRD) pattern of the?mitomycin C dihydrate?is similar to that calculated for?it, which?suggests that the purity?of?sample?is excellent.The absolute configuration of mitomycin C was determined?by X-ray single crystal diffraction?(CuKα), and a new?crystalline?dihydrate of mitomycin C had been prepared. The?experiment?result?provides?a definitive answer?to the real absolute configuration of mitomycin C and may put an end to the dispute?that baffles?researchers for decades.?At the same time, some contentious structures?about the mitomycin C in?American Pharmacopoeia?USP36-NF31,?Chinese pharmacopoeia?2015?edtion?and numbers of?literatures are marked. The absolute configuration?is?also verified?by?1D (1H?and?13C) and 2D (HSQC, HMBC,?1H-1H?COSY?and?NOESY) NMR studies?indirectly. Powder X-ray diffraction (PXRD) pattern of the?mitomycin C dihydrate?is similar to that calculated for?it, which?suggests that the purity?of?sample?is excellent.

关 键 词：CRYSTAL Structure DIHYDRATE ABSOLUTE CONFIGURATION MITOMYCIN C 

分 类 号：O61[理学—无机化学]