Aqueous-Phase, Palladium-Catalyzed Suzuki Reactions under Mild Conditions  

作　　者：Yueqin Cai Gonghua Song Zhongyuan Wu Jiawei Zhang 

机构地区：[1]School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China [2]Shanghai Key Laboratory of Chemical Biology, Institute of Pesticides & Pharmaceuticals, East China University of Science and Technology, Shanghai, China

出　　处：《Green and Sustainable Chemistry》2013年第4期1-5,共5页绿色与可持续化学（英文）

摘　　要：Water-soluble ionic liquid-supported diols have been used as phosphine-free ligands in Suzuki couplings of aryl idides/bromides/chlorides under mild conditions in aqueous solvent. It was found that 2,2-bis((1-hexylimidazolium)-mehyl) propane-1,3-diol hexafluorophosphate (4) in combination with palladium (II) salts gave the most significant catalyst. Suzuki couplings of aryl iodides/bromides occurred efficiently at room temperature in water/acetonitrile. Notably, the reactions of hydrophilic aryl bromides gave high yields in neat water. The catalyst PdCl2-4 was recycled five times in Suzuki couplings in water before catalyst activity began to significantly drop. The average yield of five cycles was >95% per cycle.Water-soluble ionic liquid-supported diols have been used as phosphine-free ligands in Suzuki couplings of aryl idides/bromides/chlorides under mild conditions in aqueous solvent. It was found that 2,2-bis((1-hexylimidazolium)-mehyl) propane-1,3-diol hexafluorophosphate (4) in combination with palladium (II) salts gave the most significant catalyst. Suzuki couplings of aryl iodides/bromides occurred efficiently at room temperature in water/acetonitrile. Notably, the reactions of hydrophilic aryl bromides gave high yields in neat water. The catalyst PdCl2-4 was recycled five times in Suzuki couplings in water before catalyst activity began to significantly drop. The average yield of five cycles was >95% per cycle.

关 键 词：SUZUKI Reaction Ionic Liquid-Supported DIOLS PHOSPHINE-FREE Ligands 

分 类 号：O6[理学—化学]