Bismuth (III) Triflate Catalyzed Multicomponent Synthesis of 2,4,5-Trisubstituted Imidazoles  

作　　者：Sophie C. Thorp Sebastian T. Chisari Rem Quintin V. David Abby Gjata Abby L. Good Erick Lopez Ram S. Mohan Sophie C. Thorp;Sebastian T. Chisari;Rem Quintin V. David;Abby Gjata;Abby L. Good;Erick Lopez;Ram S. Mohan(Laboratory for Environmentally Friendly Organic Synthesis, Department of Chemistry & Biochemistry, Illinois Wesleyan University, Bloomington, IL, USA)

机构地区：[1]Laboratory for Environmentally Friendly Organic Synthesis, Department of Chemistry & Biochemistry, Illinois Wesleyan University, Bloomington, IL, USA

出　　处：《Green and Sustainable Chemistry》2023年第3期209-215,共7页绿色与可持续化学（英文）

摘　　要：Substituted imidazoles are of interest because of their useful biological activities. While several methods have been developed for the synthesis of such compounds, some of the reported methods utilize corrosive or toxic catalysts. We report a bismuth (III) triflate catalyzed multicomponent synthesis of 2,4,5-trisubstituted imidazoles. Bismuth (III) compounds are attractive from a green chemistry perspective because they are remarkably non-toxic and non-corrosive. Multicomponent syntheses save time and generate less waste.Substituted imidazoles are of interest because of their useful biological activities. While several methods have been developed for the synthesis of such compounds, some of the reported methods utilize corrosive or toxic catalysts. We report a bismuth (III) triflate catalyzed multicomponent synthesis of 2,4,5-trisubstituted imidazoles. Bismuth (III) compounds are attractive from a green chemistry perspective because they are remarkably non-toxic and non-corrosive. Multicomponent syntheses save time and generate less waste.

关 键 词：IMIDAZOLES HETEROCYCLES Bismuth Compounds Green Chemistry Multicomponent Reactions 

分 类 号：O62[理学—有机化学]