A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI  

作　　者：Kishor S. Jain Swapnil. K. Chaudhari Nikhil S. More Kapil D. More Sachin A Wakedkar M. K. Kathiravan 

机构地区：[1]不详

出　　处：《International Journal of Organic Chemistry》2011年第2期47-52,共6页有机化学国际期刊（英文）

摘　　要：Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.

关 键 词：Microwave Assisted ORGANIC Synthesis (MAOS) 2-Amino-5-Cyano-2 6-Disubstitutedpyrimidines Α-Cyanoketene S S-ACETALS 

分 类 号：O6[理学—化学]