An Efficient Synthesis of Pyrido[2,3-<i>d</i>]pyrimidine Derivatives via One-Pot Three-Component Reaction in Aqueous Media  

作　　者：Shahrzad Abdolmohammadi Saeed Balalaie 

机构地区：[1]Department of Chemistry, Islamic Azad University, East Tehran Branch (Qiam Dasht), Tehran, Iran [2]Peptide Chemistry Research Center, K. N. Toosi University of Technology, Tehran, Iran

出　　处：《International Journal of Organic Chemistry》2012年第1期7-14,共8页有机化学国际期刊（英文）

摘　　要：A series of pyrido[2,3-d]pyrimidines derivatives have been prepared by one-pot three-component reaction of 4(6)-aminouracil, malononitrile and aromatic aldehydes. This efficient synthesis was done under microwave irradiation conditions (method A) and also using catalytic amount of diammonium hydrogen phosphate [(NH4)2HPO4] (DAHP) in aqueous media (method B). This procedure has the advantages of good yields, easy work-up, and benign environmentally friendly character. Reaction could proceed via domino Knoevenagel-Michael-cyclization reactions.A series of pyrido[2,3-d]pyrimidines derivatives have been prepared by one-pot three-component reaction of 4(6)-aminouracil, malononitrile and aromatic aldehydes. This efficient synthesis was done under microwave irradiation conditions (method A) and also using catalytic amount of diammonium hydrogen phosphate [(NH4)2HPO4] (DAHP) in aqueous media (method B). This procedure has the advantages of good yields, easy work-up, and benign environmentally friendly character. Reaction could proceed via domino Knoevenagel-Michael-cyclization reactions.

关 键 词：Diammonium Hydrogen PHOSPHATE (DAHP) Microwave Irradiation (MWI) Water in Organic Synthesis Pyrido[2 3-d]pyrimidine 

分 类 号：O6[理学—化学]