Simple Reduction of Hydantoins with Sodium Borohydride  

作　　者：Jun-Ichi Yamaguchi Emiko Shibuta Yoshie Oishi 

机构地区：[1]Department of Applied Chemistry, Kanagawa Institute of Technology, Atsugi, Japan

出　　处：《International Journal of Organic Chemistry》2014年第5期286-291,共6页有机化学国际期刊（英文）

摘　　要：The reduction of various hydantoins with sodium borohydride gave the corresponding 4-hydroxy- 2-imidazolidinones in high yields. In contrast, reduction employing a boron trifluoride etherate-sodium borohydride system generated 2-imidazolidinones. In both reductions, the reactivity of the hydantoin was dependent on its substituents. The Lewis acid-promoted reactions of a 4-hydroxy-2-imidazolidinone with nucleophiles were also investigated.The reduction of various hydantoins with sodium borohydride gave the corresponding 4-hydroxy- 2-imidazolidinones in high yields. In contrast, reduction employing a boron trifluoride etherate-sodium borohydride system generated 2-imidazolidinones. In both reductions, the reactivity of the hydantoin was dependent on its substituents. The Lewis acid-promoted reactions of a 4-hydroxy-2-imidazolidinone with nucleophiles were also investigated.

关 键 词：HYDANTOIN REDUCTION IMIDAZOLIDINONE 

分 类 号：O6[理学—化学]