FeCl₃Catalyzed One Pot Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles under Solvent-Free Conditions  

作　　者：Fatemeh Darvish Shima Khazraee 

机构地区：[1]Department of Chemistry, K.N.Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran

出　　处：《International Journal of Organic Chemistry》2015年第2期75-80,共6页有机化学国际期刊（英文）

摘　　要：An efficient procedure for the preparation of 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation of triethyl orthoformate, amine, and trimethylsilyl azide using inexpensive and environment-friendly FeCl3 as catalyst under solvent-free conditions has been reported. The reaction generates the corresponding 1-substituted tetrazole in excellent yields.An efficient procedure for the preparation of 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation of triethyl orthoformate, amine, and trimethylsilyl azide using inexpensive and environment-friendly FeCl3 as catalyst under solvent-free conditions has been reported. The reaction generates the corresponding 1-substituted tetrazole in excellent yields.

关 键 词：Iron(III) Chloride 1-Substituted-1H-1 2 3 4-Tetrazoles Amines Triethyl Orthoformate Solvent-Free TRIMETHYLSILYL AZIDE 

分 类 号：O6[理学—化学]