Synthesis and Antibacterial Activity of Aromatic Homopropargyl Alcohols  

作　　者：Christian A.Umana María L.Arias Jorge A.Cabezas 

机构地区：[1]School of Chemistry,University of Costa Rica,San José,Costa Rica [2]Faculty of Microbiology,University of Costa Rica,San José,Costa Rica

出　　处：《International Journal of Organic Chemistry》2017年第3期295-300,共6页有机化学国际期刊（英文）

摘　　要：Several aromatic homopropargyl alcohols, and derivatives were prepared by one-pot reaction of 1,3-dilithiopropyne (or its equivalent) with aldehydes and ketones. The antibacterial activity, of alcohols thus prepared, against Gram (+) and Gram (-) bacteria was tested. This activity varies depending upon substitution on the homopropargyl alcohol unit. Apparently, the benzene ring and the free hydroxyl group (or its alcoxide) are needed, in the homopropargyl alcohol unit, to be biologically active.Several aromatic homopropargyl alcohols, and derivatives were prepared by one-pot reaction of 1,3-dilithiopropyne (or its equivalent) with aldehydes and ketones. The antibacterial activity, of alcohols thus prepared, against Gram (+) and Gram (-) bacteria was tested. This activity varies depending upon substitution on the homopropargyl alcohol unit. Apparently, the benzene ring and the free hydroxyl group (or its alcoxide) are needed, in the homopropargyl alcohol unit, to be biologically active.

关 键 词：Homopropargyl Alcohols 1 3-Dilithiopropyne Antibacterial Activity 

分 类 号：O6[理学—化学]