A Mini-Review 5-Amino-N-Substituted Pyrazoles as Building Blocks for Bioactive Molecules  

作　　者：Wafa Bawazir Wafa Bawazir(Department of Chemistry, Faculty of Science, King Abdul-Aziz University, Jeddah, KSA)

机构地区：[1]Department of Chemistry, Faculty of Science, King Abdul-Aziz University, Jeddah, KSA

出　　处：《International Journal of Organic Chemistry》2020年第2期63-76,共14页有机化学国际期刊（英文）

摘　　要：In this review a five-membered heterocyclic ring having two adjacent nitrogen atoms known as Pyrazole, we have framed 5-amino-N-substituted pyrazoles in particular focusing on its substantial role as a building block and starting materials for producing enormous heterocyclic skeletons. The existence of this moiety in larger compounds renders them to expose medicinal, pharmacological and biological therapeutic activities. Enormous drugs contain 5-amino-N-substituted pyrazoles such as celecoxib anti-inflammatory, antipsychotic, anti-obesity, analgesic, and antidepressant. We reported various routes of synthesis and the use of these compounds.In this review a five-membered heterocyclic ring having two adjacent nitrogen atoms known as Pyrazole, we have framed 5-amino-N-substituted pyrazoles in particular focusing on its substantial role as a building block and starting materials for producing enormous heterocyclic skeletons. The existence of this moiety in larger compounds renders them to expose medicinal, pharmacological and biological therapeutic activities. Enormous drugs contain 5-amino-N-substituted pyrazoles such as celecoxib anti-inflammatory, antipsychotic, anti-obesity, analgesic, and antidepressant. We reported various routes of synthesis and the use of these compounds.

关 键 词：Synthesis 1 5-Disubstituted Pyrazoles Bioactive Review 

分 类 号：O62[理学—有机化学]