Synthesis, Molecular Structure, Anti-Plasmodial, Antimicrobial and Anti-Oxidant Screening of (E)-1-(Phthalazin-1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine and 1-[2-(1-(pyridine-3- yl)ethylidene)hydrazinyl]phthalazine  

作　　者：Angelbert F. Awantu Godfred A. Ayimele Jean Jules K. Bankeu Edouard A. Nantia Patrick V. T. Fokou Fabrice F. Boyom Emmanuel N. Nfor Bruno N. Lenta Silvère A. Ngouela Angelbert F. Awantu;Godfred A. Ayimele;Jean Jules K. Bankeu;Edouard A. Nantia;Patrick V. T. Fokou;Fabrice F. Boyom;Emmanuel N. Nfor;Bruno N. Lenta;Silvère A. Ngouela(Department of Chemistry, The University of Bamenda, Bambili, Cameroon;Department of Chemistry, University of Buea, Buea, Cameroon;Department of Biochemistry, The University of Bamenda, Bambili, Cameroon;Department of Biochemistry, University of Yaoundé I, Yaoundé, Cameroon;Department of Chemistry, Higher Teachers’ Training College, University of Yaoundé I, Yaoundé, Cameroon;Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon)

机构地区：[1]Department of Chemistry, The University of Bamenda, Bambili, Cameroon [2]Department of Chemistry, University of Buea, Buea, Cameroon [3]Department of Biochemistry, The University of Bamenda, Bambili, Cameroon [4]Department of Biochemistry, University of Yaoundé I, Yaoundé, Cameroon [5]Department of Chemistry, Higher Teachers’ Training College, University of Yaoundé I, Yaoundé, Cameroon [6]Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon

出　　处：《International Journal of Organic Chemistry》2021年第3期91-105,共15页有机化学国际期刊（英文）

摘　　要：Two new hydralazine hydrochloride-derived Schiff bases</span><span style="font-family:Verdana;"><span style="font-family:Verdana;">:</span></span><span style="font-family:Verdana;"> (E)-1-(Phthalazin-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine (PPEH), and 1-[2-(1-(pyridine-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">3</span><span style="font-family:Verdana;">-yl)ethylidene)hydrazinyl]phthalazine (PEHP), were synthesized and partially characterized by spectroscopic and crystallographic methods including IR and X-ray. The single-crystal X-ray diffraction (SCXRD) analysis of PEHP indicate</span><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span><span style="font-family:Verdana;"> that the hydralazine moiety of both ligands possess</span><span style="font-family:Verdana;"><span style="font-family:Verdana;">es</span></span><span style="font-family:Verdana;"> the exoc</span><span style="font-family:Verdana;">yclic C=N bond. Both, PPEH and PEHP were tested as antimicrobials and antiparasites. Just PEHP could be considered as slightly antiplasmodial and antibacterial agent. In effect, PPEH showed low antimicrobial activity against one bacterial strain with Minimum Inhibitory Concentration (MIC) value of 250 μg/ml while PEHP showed very interesting activity against 18 out of 19 bacterial strains with MIC of 31.25 </span><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span><span style="font-family:Verdana;"> 250 μg/ml compared to the standard drug, amoxicillin. PPEH and PEHP showed higher reducing activity on ferric ions compared to Vitamin C. On the other hand, both hidrazaline synthetized derivatives show</span><span style="font-family:Verdana;"><span style="font-family:Verdana;">ed</span></span><span style="font-family:Verdana;"> as better reducing agents than Vitamin C on ferric ions, while again, only the PEHP show</spTwo new hydralazine hydrochloride-derived Schiff bases</span><span style="font-family:Verdana;"><span style="font-family:Verdana;">:</span></span><span style="font-family:Verdana;"> (E)-1-(Phthalazin-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine (PPEH), and 1-[2-(1-(pyridine-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">3</span><span style="font-family:Verdana;">-yl)ethylidene)hydrazinyl]phthalazine (PEHP), were synthesized and partially characterized by spectroscopic and crystallographic methods including IR and X-ray. The single-crystal X-ray diffraction (SCXRD) analysis of PEHP indicate</span><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span><span style="font-family:Verdana;"> that the hydralazine moiety of both ligands possess</span><span style="font-family:Verdana;"><span style="font-family:Verdana;">es</span></span><span style="font-family:Verdana;"> the exoc</span><span style="font-family:Verdana;">yclic C=N bond. Both, PPEH and PEHP were tested as antimicrobials and antiparasites. Just PEHP could be considered as slightly antiplasmodial and antibacterial agent. In effect, PPEH showed low antimicrobial activity against one bacterial strain with Minimum Inhibitory Concentration (MIC) value of 250 μg/ml while PEHP showed very interesting activity against 18 out of 19 bacterial strains with MIC of 31.25 </span><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span><span style="font-family:Verdana;"> 250 μg/ml compared to the standard drug, amoxicillin. PPEH and PEHP showed higher reducing activity on ferric ions compared to Vitamin C. On the other hand, both hidrazaline synthetized derivatives show</span><span style="font-family:Verdana;"><span style="font-family:Verdana;">ed</span></span><span style="font-family:Verdana;"> as better reducing agents than Vitamin C on ferric ions, while again, only the PEHP show</sp

关 键 词：Schiff Base Hydralazine Hydrochloride Anti-Plasmodial Activity Antimicrobial Activity Anti-Oxidant Activity 

分 类 号：O17[理学—数学]