TCCA/NCS-Promoted Cascade Cyclization of <i>β</i>, <i>γ</i>-Unsaturated Compounds: Synthesis of Isoxazolines and Pyrazolines  

作　　者：Khidir Tajelseir Othman Nibras Ahmed Elaas Khidir Tajelseir Othman;Nibras Ahmed Elaas(Department of Chemistry, Faculty of Education, University of Gadarif, Gadarif, Sudan;Department of Chemistry, Faculty of Education, University of Khartoum, Khartoum, Sudan)

机构地区：[1]Department of Chemistry, Faculty of Education, University of Gadarif, Gadarif, Sudan [2]Department of Chemistry, Faculty of Education, University of Khartoum, Khartoum, Sudan

出　　处：《International Journal of Organic Chemistry》2021年第4期187-198,共12页有机化学国际期刊（英文）

摘　　要：2-Isoxazolines and 2-pyrazolines have been derived from oxime and hydrazone derivatives reacted with <i><i><span style="font-family:Verdana;">N</span></i></i><span style="font-family:Verdana;">-chlorosuccinimide (NCS) and trichloroisocyanuric acid (TCCA). Cyclization strategy is developed for the reaction of <i></i></span><i><i><span style="font-family:Verdana;">β</span></i></i><span><span style="font-family:Verdana;">, <i></i></span><i><i><span style="font-family:Verdana;">γ</span></i></i></span><span style="font-family:Verdana;">-unsaturated hydrazones with the TCCA to drive 2-pyrazolines and the reaction of <i></i></span><i><i><span style="font-family:Verdana;">β</span></i></i><span><span style="font-family:Verdana;">, <i></i></span><i><i><span style="font-family:Verdana;">γ</span></i></i></span><span style="font-family:Verdana;">-unsaturated oximes with NCS to derive 2-isoxalzolines. Structures of all new 2-isoxazolines and 2-pyrazolines have been elucidated by microanalyses, </span>^{<span style="font-family:Verdana;">1</span>}<span style="font-family:Verdana;">H, </span>^{<span style="font-family:Verdana;">13</span>}<span style="font-family:Verdana;">C NMR and Mass spectroscopies.</span>2-Isoxazolines and 2-pyrazolines have been derived from oxime and hydrazone derivatives reacted with <i><i><span style="font-family:Verdana;">N</span></i></i><span style="font-family:Verdana;">-chlorosuccinimide (NCS) and trichloroisocyanuric acid (TCCA). Cyclization strategy is developed for the reaction of <i></i></span><i><i><span style="font-family:Verdana;">β</span></i></i><span><span style="font-family:Verdana;">, <i></i></span><i><i><span style="font-family:Verdana;">γ</span></i></i></span><span style="font-family:Verdana;">-unsaturated hydrazones with the TCCA to drive 2-pyrazolines and the reaction of <i></i></span><i><i><span style="font-family:Verdana;">β</span></i></i><span><span style="font-family:Verdana;">, <i></i></span><i><i><span style="font-family:Verdana;">γ</span></i></i></span><span style="font-family:Verdana;">-unsaturated oximes with NCS to derive 2-isoxalzolines. Structures of all new 2-isoxazolines and 2-pyrazolines have been elucidated by microanalyses, </span>^{<span style="font-family:Verdana;">1</span>}<span style="font-family:Verdana;">H, </span>^{<span style="font-family:Verdana;">13</span>}<span style="font-family:Verdana;">C NMR and Mass spectroscopies.</span>

关 键 词：2-Isoxazolines 2-Pyrazolines NCS TCCA 

分 类 号：O62[理学—有机化学]