One-Pot Synthesis of Pyrido[2,3-d]pyrimidines Catalyzed by Bismuth(III)Triflate  

作　　者：Deniz Saglam Zuhal Turgut Deniz Saglam;Zuhal Turgut(Department of Chemistry, Faculty of Art and Sciences, Yildiz Technical University, Davutpasa Campus, Istanbul, Turkey)

机构地区：[1]Department of Chemistry, Faculty of Art and Sciences, Yildiz Technical University, Davutpasa Campus, Istanbul, Turkey

出　　处：《International Journal of Organic Chemistry》2022年第1期11-27,共17页有机化学国际期刊（英文）

摘　　要：Synthesis of uracil derivatives, such as pyrido[2,3-d]pyrimidine, is very important for the pharmaceutical industry due to their many biological activities. In our continuing efforts into the development of new synthetic strategies for the preparation of heterocyclic compounds in this study, we performed reflux reactions with the catalyst Bi(OTf)₃ by using a one-pot, threecomponent method. The one-pot, three-component condensation of 6-amino-1,3-dimethyluracil, with arylaldehydes and malononitrile to generate a series of 7-aminopyrido[2,3-d]pyrimidine-6-carbonitrile derivatives has been carried out in the presence of bismuth triflate as a green and reusable catalyst.Synthesis of uracil derivatives, such as pyrido[2,3-d]pyrimidine, is very important for the pharmaceutical industry due to their many biological activities. In our continuing efforts into the development of new synthetic strategies for the preparation of heterocyclic compounds in this study, we performed reflux reactions with the catalyst Bi(OTf)₃ by using a one-pot, threecomponent method. The one-pot, three-component condensation of 6-amino-1,3-dimethyluracil, with arylaldehydes and malononitrile to generate a series of 7-aminopyrido[2,3-d]pyrimidine-6-carbonitrile derivatives has been carried out in the presence of bismuth triflate as a green and reusable catalyst.

关 键 词：Bismuth Triflate Pyrido[2 3-d]pyrimidine ONE-POT Biological Activity 

分 类 号：O626[理学—有机化学]