Aminated (Cyclopropylmethyl)Phosphonates: Synthesis and Anti-Pancreatic Cancer Activity  

作　　者：Abed Al Aziz Al Quntar Ibrahim Abasy Hasan Dweik Michel Maffei Valery M. Dembitsky Abed Al Aziz Al Quntar;Ibrahim Abasy;Hasan Dweik;Michel Maffei;Valery M. Dembitsky(Department of Chemistry and Chemical Technology, Faculty of Science and Technology, Al-Quds University, Jerusalem, Palestine;Department of Microbiology and Immunology, Al-Quds University, Jerusalem, Palestine;Institut des Sciences Moleculaires de Marseille (iSm2), Aix-Marseille University, CNRS, Centrale Marseille, Marseille, France;Bio-Geo-Chem Laboratories, Ltd., Aliso Viejo, USA)

机构地区：[1]Department of Chemistry and Chemical Technology, Faculty of Science and Technology, Al-Quds University, Jerusalem, Palestine [2]Department of Microbiology and Immunology, Al-Quds University, Jerusalem, Palestine [3]Institut des Sciences Moleculaires de Marseille (iSm2), Aix-Marseille University, CNRS, Centrale Marseille, Marseille, France [4]Bio-Geo-Chem Laboratories, Ltd., Aliso Viejo, USA

出　　处：《International Journal of Organic Chemistry》2023年第4期129-136,共8页有机化学国际期刊(英文)

摘　　要：Buoyed by the extensive research on the wide-range biological activities of aminophosphonates, a novel class of aminated (cyclopropylmethyl)phosphor-nates compounds was synthesized from diethyl ((1-(3-chloropropyl)cyclopropyl)methyl)phosphonate and various amines in the presence of Hunig’s base. Upon biological activity screening these compounds demonstrated encouraging anti-pancreatic cancer properties at low micromolar concentrations.Buoyed by the extensive research on the wide-range biological activities of aminophosphonates, a novel class of aminated (cyclopropylmethyl)phosphor-nates compounds was synthesized from diethyl ((1-(3-chloropropyl)cyclopropyl)methyl)phosphonate and various amines in the presence of Hunig’s base. Upon biological activity screening these compounds demonstrated encouraging anti-pancreatic cancer properties at low micromolar concentrations.

关 键 词：PHOSPHONATES AMINOPHOSPHONATES Pancreatic Cancer CANCER Cyclopropylphosphonates 

分 类 号：O62[理学—有机化学]