Evaluation of Pesticidal Activities of Lignans Isolated from Piper cubeba Fruits  

作　　者：Victor Pena Ribeiro Joanna Bajsa-Hirschel Prabin Tamang Alden S. Estep Jairo Kenupp Bastos Kumudini M. Meepagala Victor Pena Ribeiro;Joanna Bajsa-Hirschel;Prabin Tamang;Alden S. Estep;Jairo Kenupp Bastos;Kumudini M. Meepagala(Agricultural Research Service, U.S. Department of Agriculture, Natural Products Utilization Research Unit, Oxford, MS, USA;USDA-ARS, Mosquito and Fly Research Unit, Gainesville, FL, USA;School of Pharmaceutical Sciences of Ribeiro Preto, University of So Paulo, So Paulo, SP, Brazil)

机构地区：[1]Agricultural Research Service, U.S. Department of Agriculture, Natural Products Utilization Research Unit, Oxford, MS, USA [2]USDA-ARS, Mosquito and Fly Research Unit, Gainesville, FL, USA [3]School of Pharmaceutical Sciences of Ribeiro Preto, University of So Paulo, So Paulo, SP, Brazil

出　　处：《Journal of Agricultural Chemistry and Environment》2024年第4期341-354,共14页农业化学和环境（英文）

摘　　要：The identification of natural, plant-derived compounds with pesticidal properties is crucial for developing environmentally sustainable alternatives to synthetic pesticides. In this study, four major lignans—dihydroclusin, cubebin, clusin, and yatein—were isolated from the crude extract of Piper cubeba fruit. Phytotoxicity assays revealed herbicidal activity against Agrostis stolonifera, with dihydroclusin and clusin exhibiting the highest efficacy, inhibiting seed germination by 50% and showing IC50 values of 2.9 µM and 45 µM, respectively, against Lemna paucicostata. Additionally, all compounds, except dihydroclusin, demonstrated fungicidal activity against the strawberry anthracnose pathogen Colletotrichum fragariae. Moreover, only dihydroclusin exhibited larvicidal activity against Aedes aegypti, causing 96% mortality of mosquito larvae at the 100-ppm concentration tested. These findings highlight the broad-spectrum bioactivity of Piper cubeba lignans, suggesting their potential as alternative agents of synthetic pesticides for managing agricultural pests.The identification of natural, plant-derived compounds with pesticidal properties is crucial for developing environmentally sustainable alternatives to synthetic pesticides. In this study, four major lignans—dihydroclusin, cubebin, clusin, and yatein—were isolated from the crude extract of Piper cubeba fruit. Phytotoxicity assays revealed herbicidal activity against Agrostis stolonifera, with dihydroclusin and clusin exhibiting the highest efficacy, inhibiting seed germination by 50% and showing IC50 values of 2.9 µM and 45 µM, respectively, against Lemna paucicostata. Additionally, all compounds, except dihydroclusin, demonstrated fungicidal activity against the strawberry anthracnose pathogen Colletotrichum fragariae. Moreover, only dihydroclusin exhibited larvicidal activity against Aedes aegypti, causing 96% mortality of mosquito larvae at the 100-ppm concentration tested. These findings highlight the broad-spectrum bioactivity of Piper cubeba lignans, suggesting their potential as alternative agents of synthetic pesticides for managing agricultural pests.

关 键 词：Piper cubeba Lignans Herbicidal FUNGICIDAL LARVICIDAL 

分 类 号：O62[理学—有机化学]