Antioxidant Activity Evaluation in a Series of Heterocyclic Compounds Derived from 1,8-Diaminonaphthalene  

作　　者：Tuo Nanou Tiéba Kangah Niameke Jean Baptiste Ballo Daouda Kablan Ahmont Landry Claude Kodjo Charles Guillaume Yapo Ossey Bernard Ziao Nahossé Tuo Nanou Tiéba;Kangah Niameke Jean Baptiste;Ballo Daouda;Kablan Ahmont Landry Claude;Kodjo Charles Guillaume;Yapo Ossey Bernard;Ziao Nahossé(Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Université NanguiAbrogoua, Abidjan, Côte d’Ivoire;Laboratoire de Chimie Organique Heterocyclique URAC 21, Pôle de Compétence Pharmacochimie, Faculté des Sciences, Université’ Mohammed V, Rabat, Moroc;Laboratoire de Constitution et Réaction de la Matière (LCRM), UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire;UFR Des Sciences Biologiques, Université Péléforo Gon Coulibaly de Korhogo, Korhogo, Côte d’Ivoire;Laboratoire Centrale de l’Environnement (LCE), Centre Ivoirien Antipollution (CIAPOL), Abidjan, Côte d’Ivoire;Laboratoire des Sciences de l’Environnement (LSE), UFR SGE, Université Nangui Abrogoua, Abidjan, Côte d’Ivoire)

机构地区：[1]Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Université NanguiAbrogoua, Abidjan, Cô te d’Ivoire [2]Laboratoire de Chimie Organique Heterocyclique URAC 21, Pô le de Compétence Pharmacochimie, Faculté des Sciences, Université’ Mohammed V, Rabat, Moroc [3]Laboratoire de Constitution et Réaction de la Matière (LCRM), UFR Sciences des Structures de la Matière et Technologie, Université Félix Houphouë t-Boigny, Abidjan, Cô te d’Ivoire [4]UFR Des Sciences Biologiques, Université Péléforo Gon Coulibaly de Korhogo, Korhogo, Cô te d’Ivoire [5]Laboratoire Centrale de l’Environnement (LCE), Centre Ivoirien Antipollution (CIAPOL), Abidjan, Cô te d’Ivoire [6]Laboratoire des Sciences de l’Environnement (LSE), UFR SGE, Université Nangui Abrogoua, Abidjan, Cô te d’Ivoire

出　　处：《Journal of Biophysical Chemistry》2021年第1期1-9,共9页生物物理化学（英文）

摘　　要：From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl, the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in <i>para</i> position has the lowest activity in both cases. Therefore the <i>para</i> position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.From (2,3-dihydro-1<i>H</i>-perimidin-2-yl)-phenyl, the substitution of OH group in <i>ortho</i> or <i>para</i> position on the phenyl ring, allows us to synthesize the studied compounds. These three compounds have been characterized by conventional spectroscopic methods (NMR and MS). The interest of this work is to review the antioxidant activity of our compounds. The antioxidant activity screening carried out according to FRAP and DPPH methods revealed significant anti-free radical properties for compounds 1 and 2 even at low concentrations. In contrast to the compound 2, compound 3 for which the OH group is substituted in <i>para</i> position has the lowest activity in both cases. Therefore the <i>para</i> position seems to be the least sensitive position to increase the antioxidant activity of this pharmacophore.

关 键 词：PERIMIDINE SPECTROMETRY Antioxidant Activity 2 2-Diphenyl-1-Picrylhydrazyl Method and Ferric Reducing Antioxidant Power Method 

分 类 号：O62[理学—有机化学]