Intercalation of Ciprofloxacin in Naturally Occurring Smectite from Bana: Potentiality as Drug Delivery System and Antimicrobial Effects on <i>Escherichia coli</i>and <i>Staphylococcus aureus</i>  

作　　者：Carine Feudjio Memenfo Nicolas Tabary Jean Aimé Mbey Stéphanie Degoutin Frédéric Cazaux Maryse Bacquet Mickaël Maton Bernard Martel Daniel Njopwouo Carine Feudjio Memenfo;Nicolas Tabary;Jean Aimé Mbey;Stéphanie Degoutin;Frédéric Cazaux;Maryse Bacquet;Mickaël Maton;Bernard Martel;Daniel Njopwouo(Laboratory of Applied Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon;Unité Matériaux et Transformations (UMET), UMR 8207, CNRS, INRA, ENSCL, University of Lille, Lille, France;INSERM, CHU Lille, U1008-Controlled Drug Delivery Systems and Biomaterials, University of Lille, Lille, France)

机构地区：[1]Laboratory of Applied Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon [2]Unité Matériaux et Transformations (UMET), UMR 8207, CNRS, INRA, ENSCL, University of Lille, Lille, France [3]INSERM, CHU Lille, U1008-Controlled Drug Delivery Systems and Biomaterials, University of Lille, Lille, France

出　　处：《Journal of Materials Science and Chemical Engineering》2021年第8期21-40,共20页材料科学与化学工程（英文）

摘　　要：Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loaded-clays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. <i>In vitro</i> release studies have been done in gastric and phosphate buffer experimental mediums;bacteriological studies have been made up on <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. X-ray diffractometry patterns of loaded compounds show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed Infrared spectrometry spectra, appearance of CFX characteristic bands and shifting of certain bands already presents on clay confirmed CFX intercalation. After 96 h of CFX released from release mediums, prolonged and continue profiles have been observed. Diffusion tests displayed an inhibition radius of ~2 cm on gelose seeded with <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> due to CFX. The overall results show a modified release of ciprofloxacin with an effective antibacterial activity, giving the way for a new ciprofloxacin drug delivery system using Bana clay as carrier.Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loaded-clays have been evaluated as drug delivery system. Raw clays and CFX loaded compounds have been characterized by some physico-chemicals methods. <i>In vitro</i> release studies have been done in gastric and phosphate buffer experimental mediums;bacteriological studies have been made up on <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. X-ray diffractometry patterns of loaded compounds show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed Infrared spectrometry spectra, appearance of CFX characteristic bands and shifting of certain bands already presents on clay confirmed CFX intercalation. After 96 h of CFX released from release mediums, prolonged and continue profiles have been observed. Diffusion tests displayed an inhibition radius of ~2 cm on gelose seeded with <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> due to CFX. The overall results show a modified release of ciprofloxacin with an effective antibacterial activity, giving the way for a new ciprofloxacin drug delivery system using Bana clay as carrier.

关 键 词：Antibacterial Effect Drug Delivery System Clay CIPROFLOXACIN INTERCALATION 

分 类 号：O62[理学—有机化学]