Synthesis, Structural Characterization and Antimicrobial Activity of a Novel Cobalt(II) Complex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One  

作　　者：Emeline Sorelle Mefouegang Claudelle Sybilline Anensong Djadock Golngar Djimassingar Gabriel Tchuente Kamsu Donald Raoul Tchuifon Tchuifon Alain Charly Tagne Kuate Dirk Bockfeld Jean Ngoune Emeline Sorelle Mefouegang;Claudelle Sybilline Anensong Djadock;Golngar Djimassingar;Gabriel Tchuente Kamsu;Donald Raoul Tchuifon Tchuifon;Alain Charly Tagne Kuate;Dirk Bockfeld;Jean Ngoune(Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;Department of Fundamental Sciences, Mongo Polytechnique University Institute (IUPM), Mongo, Chad;Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;Department of Process Engineering, Laboratory of Energy, Materials, Modeling and Method, National Higher Polytechnic School of Douala, University of Douala, Douala, Cameroon;Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Braunschweig, Germany)

机构地区：[1]Research Unit of Noxious Chemistry and Environmental Engineering, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon [2]Department of Fundamental Sciences, Mongo Polytechnique University Institute (IUPM), Mongo, Chad [3]Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon [4]Department of Process Engineering, Laboratory of Energy, Materials, Modeling and Method, National Higher Polytechnic School of Douala, University of Douala, Douala, Cameroon [5]Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Braunschweig, Germany

出　　处：《Journal of Materials Science and Chemical Engineering》2023年第8期109-126,共18页材料科学与化学工程（英文）

摘　　要：New cobalt(II) complex, [Co(O₂C₁₅H₁₁N₂S)₂(OH₂)₂]∙2H₂O (1∙2H₂O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl)₂∙6H₂O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1∙2H₂O. Compound 1∙2H₂O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1∙2H₂O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1∙2H₂O displayed moderate activity (10 ∙2H₂O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus).New cobalt(II) complex, [Co(O₂C₁₅H₁₁N₂S)₂(OH₂)₂]∙2H₂O (1∙2H₂O), has been synthesized upon reaction of cobalt chloride hexahydrate (Co(Cl)₂∙6H₂O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single crystal X-ray diffraction (XRD), spectroscopic methods, and microelemental analyses were used to characterize 1∙2H₂O. Compound 1∙2H₂O crystallizes in the orthorhombic crystal system with a Pbca space group and with the cobalt atom being pseudo-octahedral coordinated. The broth microdilution technique was used to screen the free ligand (HL) and the complex (1∙2H₂O) for antimicrobial activities. HL has a low activity (MIC > 100 μg/mL) on all microorganisms, whereas compound 1∙2H₂O displayed moderate activity (10 ∙2H₂O exhibited bactericidal and fungicidal activity respectively on all the bacteria and yeasts tested. These findings reveal that the antimicrobial activity of HL was enhanced upon coordination to Co(II) ion against all microorganisms (bacteria and fungus).

关 键 词：COBALT ACYLPYRAZOLONE X-Ray Diffraction Antimicrobial Activity 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One 

分 类 号：O62[理学—有机化学]