Theoretical Study of Benzothiazole and Its Derivatives: Molecular Structure, Spectroscopic Properties, NBO, MEP and TD-DFT Analyses  

作　　者：Konaté Abdoulaye Bédé Affoué Lucie Ouattara Lamoussa Koné Soleymane Bamba Kafoumba Konaté Abdoulaye;Bédé Affoué Lucie;Ouattara Lamoussa;Koné Soleymane;Bamba Kafoumba(Laboratory of Constitution and Reaction of Matter, University Félix Houphouë,t-Boigny, Abidjan, Ivory Coast;Department of Marine Sciences, University of San-Pedro, San-Pedro, Ivory Coast;Laboratory of Thermodynamics and Physico-Chemistry of Environment, University Nangui Abrogoua, Abidjan, Ivory Coast)

机构地区：[1]Laboratory of Constitution and Reaction of Matter, University Félix Houphouë,t-Boigny, Abidjan, Ivory Coast [2]Department of Marine Sciences, University of San-Pedro, San-Pedro, Ivory Coast [3]Laboratory of Thermodynamics and Physico-Chemistry of Environment, University Nangui Abrogoua, Abidjan, Ivory Coast

出　　处：《Journal of Materials Science and Chemical Engineering》2024年第3期31-50,共20页材料科学与化学工程（英文）

摘　　要：Benzothiazole (BTH) and its derivatives are organic molecules with biologic actions. Because of their many applications, they are produced on a massive scale and used in a number of environmental compartments. Their discharge into water produces environmental problems, exposing our environment to public health problems. A solution that can contribute to their deterioration is becoming a necessity. For this reason, a conceptual analysis of the reactivity of benzothiazole and four of its compounds was undertaken in order to investigate certain aspects of their biodegradability. A theoretical investigations of the compounds studied were conducted in the gas and water phases with the most widely used density functional theory method, Becke-3-Parameter-Lee-Yang-Parr (B3LYP) with 6-31G+ (d, p) basis. Reactivity study calculated global indices of reactivity revealed that 2-SCH3_BTH is the most reactive. Dipole moment values analysis reveals that 2-NH2_BTH is the most soluble in water, while the lipophilicity shows that 2-NH2_BTH is the most hydrophilic compound. Thermodynamic parameters values reflect that reactions are respectively exothermic and spontaneous. By analyzing an Electrostatic Molecular Potential (EMP) map, researchers can pinpoint reactive sites on a molecule and anticipate its reactivity. This assessment is further enhanced by incorporating global and local reactivity descriptors. Additionally, an exploration of frontier molecular orbitals offers valuable insights into the molecule’s charge transfer characteristics. Moreover, a combined examination of internal and external molecular interactions unveils hyperconjugative interactions arising from charge delocalization, as elucidated through natural bond orbital (NBO) analysis.Benzothiazole (BTH) and its derivatives are organic molecules with biologic actions. Because of their many applications, they are produced on a massive scale and used in a number of environmental compartments. Their discharge into water produces environmental problems, exposing our environment to public health problems. A solution that can contribute to their deterioration is becoming a necessity. For this reason, a conceptual analysis of the reactivity of benzothiazole and four of its compounds was undertaken in order to investigate certain aspects of their biodegradability. A theoretical investigations of the compounds studied were conducted in the gas and water phases with the most widely used density functional theory method, Becke-3-Parameter-Lee-Yang-Parr (B3LYP) with 6-31G+ (d, p) basis. Reactivity study calculated global indices of reactivity revealed that 2-SCH3_BTH is the most reactive. Dipole moment values analysis reveals that 2-NH2_BTH is the most soluble in water, while the lipophilicity shows that 2-NH2_BTH is the most hydrophilic compound. Thermodynamic parameters values reflect that reactions are respectively exothermic and spontaneous. By analyzing an Electrostatic Molecular Potential (EMP) map, researchers can pinpoint reactive sites on a molecule and anticipate its reactivity. This assessment is further enhanced by incorporating global and local reactivity descriptors. Additionally, an exploration of frontier molecular orbitals offers valuable insights into the molecule’s charge transfer characteristics. Moreover, a combined examination of internal and external molecular interactions unveils hyperconjugative interactions arising from charge delocalization, as elucidated through natural bond orbital (NBO) analysis.

关 键 词：BENZOTHIAZOLE REACTIVITY DFT/B3LYP Stability TD-DFT 

分 类 号：O62[理学—有机化学]