Preliminary Investigation of Copper(II) Ion Binding or Complex Coordination in Lysozeme Molecules  

作　　者：Kou Takahashi Ryotaro Miyazaki Daisuke Nakane Temitayo O. Aiyelabola Takashiro Akitsu Kou Takahashi;Ryotaro Miyazaki;Daisuke Nakane;Temitayo O. Aiyelabola;Takashiro Akitsu(Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo, Japan;Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-Ife, Nigeria)

机构地区：[1]Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo, Japan [2]Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-Ife, Nigeria

出　　处：《Journal of Materials Science and Chemical Engineering》2024年第4期98-103,共6页材料科学与化学工程（英文）

摘　　要：Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed amino acid derivative Schiff base copper(II) complexes were obtained. Herein we discuss primarily on the binding mode of copper(II) of the complexes obtained with egg white lysozyme. The electron density of copper(II) ions was confirmed by X-ray crystal structure analysis. The Val derivative Schiff base copper(II) complex was weakly bound at Arg114 of egg white lysozyme. In other copper(II) complexes, binding of copper(II) ions with dissociated ligands to various residues was observed. The binding sites of copper(II) ions were compared with computational scientific predictions.Hydrophobic Val derivative Schiff base copper(II) complexes and dipeptide (AlaAla, GlyGly) derivative Schiff base copper(II) complexes were introduced into egg white lysozyme. X-ray crystal structure analysis revealed amino acid derivative Schiff base copper(II) complexes were obtained. Herein we discuss primarily on the binding mode of copper(II) of the complexes obtained with egg white lysozyme. The electron density of copper(II) ions was confirmed by X-ray crystal structure analysis. The Val derivative Schiff base copper(II) complex was weakly bound at Arg114 of egg white lysozyme. In other copper(II) complexes, binding of copper(II) ions with dissociated ligands to various residues was observed. The binding sites of copper(II) ions were compared with computational scientific predictions.

关 键 词：COPPER Schiff Base LYSOZYME Metal-Protein Binding Computational Methods 

分 类 号：O62[理学—有机化学]