Development of Polycaprolactone/Poly(Vinyl Alcohol)/Clay Microparticles by Spray Drying  

作　　者：Mariana Sato de S. de B. Monteiro Claudia Lopes Rodrigues Eduardo Miguez Maria Inês B. Tavares Mariana Sato de S. de B. Monteiro;Claudia Lopes Rodrigues;Eduardo Miguez;Maria Inês B. Tavares(Instituto de Macromoléculas Professora Eloisa, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco J, Cidade Universitária, Ilha do Fundao, Rio de Janeiro, Brazil;Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Bloco L, Cidade Universitária, Ilha do Fundao, Rio de Janeiro, Brazil)

机构地区：[1]Instituto de Macromoléculas Professora Eloisa, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco J, Cidade Universitária, Ilha do Fundao, Rio de Janeiro, Brazil [2]Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Bloco L, Cidade Universitária, Ilha do Fundao, Rio de Janeiro, Brazil

出　　处：《Materials Sciences and Applications》2016年第10期575-592,共18页材料科学与应用期刊（英文）

摘　　要：In this study, nanostructured microparticles was developed with polycaprolactone (PCL), poly(vinyl alcohol) (PVAL) and nanoparticles of the commercial sodium clay NT-25®by using the spray drying technique. The systems obtained were characterized by Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic Laser Light Scattering (DLS) and Differential Scanning Calorimetry (DSC). The NMR ¹³C and FTIR techniques showed that both polymers were present in the microparticles and the DSC analysis revealed a small variation in the glass transition temperature of the PCL. The XRD and SEM analyses showed that the microparticles produced were amorphous and had a concave morphology. The NT-25 nanoload reduced the microparticles’ size due to the multiple interactions formed in the hybrid nanocomposite material. Therefore, it was possible to develop microparticles by using biodegradable and biocompatible polymers, with different polarities, allowing the incorporation of hydrophilic and hydrophobic materials and enabling the inclusion of otherwise incompatible materials in the same system.In this study, nanostructured microparticles was developed with polycaprolactone (PCL), poly(vinyl alcohol) (PVAL) and nanoparticles of the commercial sodium clay NT-25®by using the spray drying technique. The systems obtained were characterized by Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic Laser Light Scattering (DLS) and Differential Scanning Calorimetry (DSC). The NMR ¹³C and FTIR techniques showed that both polymers were present in the microparticles and the DSC analysis revealed a small variation in the glass transition temperature of the PCL. The XRD and SEM analyses showed that the microparticles produced were amorphous and had a concave morphology. The NT-25 nanoload reduced the microparticles’ size due to the multiple interactions formed in the hybrid nanocomposite material. Therefore, it was possible to develop microparticles by using biodegradable and biocompatible polymers, with different polarities, allowing the incorporation of hydrophilic and hydrophobic materials and enabling the inclusion of otherwise incompatible materials in the same system.

关 键 词：MICROPARTICLES Spray Drying POLYCAPROLACTONE Poly(Vinyl Alcohol) Sodium Clay NT-25 

分 类 号：O63[理学—高分子化学]