TsOH·H₂O-Catalyzed Friedel-Crafts of Indoles of 3-Hydroxyisobenzofuran-1(3<i>H</i>)-One with Indoles: Highly Synthesis of 3-Indolyl-Substituted Phthalides  

作　　者：Hongying Tang Xinyu Zhang Airu Song Zhongbiao Zhang 

机构地区：[1]Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal University, Tianjin, CHINA

出　　处：《Modern Research in Catalysis》2012年第2期11-14,共4页催化剂现代研究（英文）

摘　　要：An efficient and facile method for the synthesis of 3-indolyl-substituted phthalides by Friedel-Crafts alkylation of indoles with 3-hydroxyisobenzofuran-1(3H)-one has been developed. Using only 2 mol-% TsOH·H2O as the catalyst, various substituted indoles can react smoothly at room temperature to give the corresponding phthalides products in good to excellent yields (up to 96%).An efficient and facile method for the synthesis of 3-indolyl-substituted phthalides by Friedel-Crafts alkylation of indoles with 3-hydroxyisobenzofuran-1(3H)-one has been developed. Using only 2 mol-% TsOH·H2O as the catalyst, various substituted indoles can react smoothly at room temperature to give the corresponding phthalides products in good to excellent yields (up to 96%).

关 键 词：Synthesis 3-Indolyl-Substituted PHTHALIDES FRIEDEL-CRAFTS Alkylation 3-Hydroxyisobenzofuran-1(3H)-One Indole 

分 类 号：O6[理学—化学]